Xiaozheng Liu1, Zhongwei Guo2, Yanping Ding3, Jiapeng Li2, Gang Wang2, Hongtao Hou2, Xingli Chen2, Enyan Yu4. 1. China-USA Neuroimaging Research Institute, Department of Radiology of the Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China. 2. Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310012, China. 3. Hangzhou Sanatorium of People's Liberation Army, Hangzhou, Zhejiang, 310007, China. 4. People's Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310014, China. yuenyan@aliyun.com.
Abstract
PURPOSE: As one of the most common mental disorders and the most important precursor of suicide in Alzheimer's disease (AD), depression is associated with a decline in both well-being and daily functioning. At present, the diagnosis of AD patients with depression (D-AD) is largely dependent on clinical signs and symptoms, and the precise neural correlate underlying D-AD is still not fully understood. METHODS: The current study sought to investigate low-frequency oscillations at the voxel level in D-AD patients based on the amplitude of low-frequency fluctuations (ALFF) measured using resting-state functional magnetic resonance imaging. We examined 22 D-AD patients and 21 non-depressed AD (nD-AD) patients. RESULTS: The results revealed that D-AD patients exhibited increased ALFF values in the left caudate and thalamus and decreased ALFF values in the left middle temporal pole compared with nD-AD patients. CONCLUSION: These findings may provide further insight into the underlying neuropathophysiology of AD with depression.
PURPOSE: As one of the most common mental disorders and the most important precursor of suicide in Alzheimer's disease (AD), depression is associated with a decline in both well-being and daily functioning. At present, the diagnosis of ADpatients with depression (D-AD) is largely dependent on clinical signs and symptoms, and the precise neural correlate underlying D-AD is still not fully understood. METHODS: The current study sought to investigate low-frequency oscillations at the voxel level in D-ADpatients based on the amplitude of low-frequency fluctuations (ALFF) measured using resting-state functional magnetic resonance imaging. We examined 22 D-ADpatients and 21 non-depressed AD (nD-AD) patients. RESULTS: The results revealed that D-ADpatients exhibited increased ALFF values in the left caudate and thalamus and decreased ALFF values in the left middle temporal pole compared with nD-ADpatients. CONCLUSION: These findings may provide further insight into the underlying neuropathophysiology of AD with depression.
Entities:
Keywords:
Alzheimer’s disease; Amplitude of low-frequency fluctuations; Depression; Functional magnetic resonance imaging
Authors: Theodore D Satterthwaite; Daniel H Wolf; James Loughead; Kosha Ruparel; Mark A Elliott; Hakon Hakonarson; Ruben C Gur; Raquel E Gur Journal: Neuroimage Date: 2012-01-02 Impact factor: 6.556