Literature DB >> 28580519

Psychopharmacological Effects of JNK Inhibitor in Posthypoxic Encephalopathy and Mechanisms of Their Development.

G N Zyuz'kov1,2, N I Suslov3, T N Povet'eva3, Yu V Nesterova3, O G Afanas'eva3, E V Udut3, L A Miroshnichenko3, E V Simanina3, T Yu Polyakova3, L A Stavrova3, A V Chaikovskii3, P V Kul'pin3, V V Udut3,4, A M Dygai3, V V Zhdanov3.   

Abstract

Psychopharmacological effects of JNK inhibitor were studied using a mouse model of posthypoxic encephalopathy. The preparation exhibited a pronounced cerebroprotective effect manifested in normalization of orientation and exploratory behavior and conditioned responses in posthypoxic mice. These effects were accompanied by marked elevation of neural stem cell content in the paraventricular region of the brain.

Entities:  

Keywords:  JNK; cerebroprotective pharmacology; hypoxia; neural stem cells; regenerative medicine

Mesh：

Substances：

Year:  2017        PMID： 28580519     DOI： 10.1007/s10517-017-3727-9

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  2 in total

1.  Role of JNK in the Regulation of Xenobiotic Metabolizing Function of Hepatocytes.

Authors:  O S Bryushinina; Yu G Zyuz'kova; E A Yanovskaya; N Y Abdrashitova; G A Frelikh; A P Lakeev; D V Tsuran; V V Udut; G N Zyuz'kov
Journal:  Bull Exp Biol Med       Date:  2021-12-02       Impact factor: 0.804

2.  Role of JNK and p53 in Implementation of Functions of Various Types of Regeneration-Competent Cells of the Nervous Tissue.

Authors:  G N Zyuz'kov; V V Zhdanov; L A Miroshnichenko; T Yu Polyakova; E V Simanina; L A Stavrova; M G Danilets; V I Agafonov; A V Chaikovskii
Journal:  Bull Exp Biol Med       Date:  2021-07-23       Impact factor: 0.804
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.