Literature DB >> 28580379

Synthesis of 2-Oxo-1, 2-Dihydroquinoline Chemotype with Multiple Attachment Points as Novel Screening Compounds for Drug Discovery.

Alexander V Kurkin1, Andrea Altieri1, Ivan A Andreev1, Asim K Debnath2.   

Abstract

The 2-oxo-1, 2-dihydroquinoline Chemotype is well represented among screening compound collection. However, the chemical space of 2-oxo-1, 2-dihydroquinoline has not been thoroughly investigated. In this work we report the synthesis of a small but novel 2-oxo-1, 2-dihydroquinoline compound array for screening purposes, especially in drug discovery, possessing three convenient point of diversity.

Entities:  

Keywords:  2-oxo-1, 2-dihydroquinoline; Chemical scaffold; Chemotype; Drugs; Guanidine; Natural products; Screening compounds; Synthesis

Year:  2016        PMID： 28580379      PMCID： PMC5455343     

Source DB:  PubMed          Journal:  JSM Chem        ISSN： 2334-1831


  9 in total

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Journal:  Nucleic Acids Res       Date:  2000-01-01       Impact factor: 16.971

2.  A general and efficient method for the formylation of aryl and heteroaryl bromides.

Authors:  Stefan Klaus; Helfried Neumann; Alexander Zapf; Dirk Strübing; Sandra Hübner; Juan Almena; Thomas Riermeier; Peter Gross; Martin Sarich; Wolf-Rüdiger Krahnert; Kai Rossen; Matthias Beller
Journal:  Angew Chem Int Ed Engl       Date:  2005-12-16       Impact factor: 15.336

3.  pH triggered self-assembly of core cross-linked star polymers possessing thermoresponsive cores.

Authors:  Alexander W Jackson; David A Fulton
Journal:  Chem Commun (Camb)       Date:  2011-05-23       Impact factor: 6.222

4.  Potent and selective non-benzodioxole-containing endothelin-A receptor antagonists.

Authors:  A S Tasker; B K Sorensen; H S Jae; M Winn; T W von Geldern; D B Dixon; W J Chiou; B D Dayton; S Calzadila; L Hernandez; K C Marsh; J R WuWong; T J Opgenorth
Journal:  J Med Chem       Date:  1997-01-31       Impact factor: 7.446

Review 5.  The chemistry and biology of organic guanidine derivatives.

Authors:  Roberto G S Berlinck; Amaro E Trindade-Silva; Mario F C Santos
Journal:  Nat Prod Rep       Date:  2012-09-20       Impact factor: 13.423

6.  3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists. Part 2.

Authors:  Robert Epple; Mihai Azimioara; Ross Russo; Yongping Xie; Xing Wang; Christopher Cow; John Wityak; Don Karanewsky; Badry Bursulaya; Andreas Kreusch; Tove Tuntland; Andrea Gerken; Maya Iskandar; Enrique Saez; H Martin Seidel; Shin-Shay Tian
Journal:  Bioorg Med Chem Lett       Date:  2006-08-22       Impact factor: 2.823

7.  Synthesis, structure-activity relationship, and pharmacological studies of novel melanin-concentrating hormone receptor 1 antagonists 3-aminomethylquinolines: reducing human ether-a-go-go-related gene (hERG) associated liabilities.

Authors:  Shizuo Kasai; Makoto Kamata; Shinichi Masada; Jun Kunitomo; Masahiro Kamaura; Tomohiro Okawa; Kazuaki Takami; Hitomi Ogino; Yoshihide Nakano; Shuntarou Ashina; Kaoru Watanabe; Tomoko Kaisho; Yumi N Imai; Sunghi Ryu; Masaharu Nakayama; Yasutaka Nagisa; Shiro Takekawa; Koki Kato; Toshiki Murata; Nobuhiro Suzuki; Yuji Ishihara
Journal:  J Med Chem       Date:  2012-04-23       Impact factor: 7.446

8.  Antiestrogens. 2. Structure-activity studies in a series of 3-aroyl-2-arylbenzo[b]thiophene derivatives leading to [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl] [4-[2-(1-piperidinyl)ethoxy]-phenyl]methanone hydrochloride (LY156758), a remarkably effective estrogen antagonist with only minimal intrinsic estrogenicity.

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Journal:  J Med Chem       Date:  1984-08       Impact factor: 7.446

9.  DrugBank 3.0: a comprehensive resource for 'omics' research on drugs.

Authors:  Craig Knox; Vivian Law; Timothy Jewison; Philip Liu; Son Ly; Alex Frolkis; Allison Pon; Kelly Banco; Christine Mak; Vanessa Neveu; Yannick Djoumbou; Roman Eisner; An Chi Guo; David S Wishart
Journal:  Nucleic Acids Res       Date:  2010-11-08       Impact factor: 16.971
  9 in total

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