Literature DB >> 28579611

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.

Mark C Field, David Horn, Alan H Fairlamb, Michael A J Ferguson, David W Gray, Kevin D Read, Manu De Rycker, Leah S Torrie, Paul G Wyatt, Susan Wyllie, Ian H Gilbert.   

Abstract

Year:  2017        PMID： 28579611     DOI： 10.1038/nrmicro.2017.69

Source DB:  PubMed          Journal:  Nat Rev Microbiol        ISSN： 1740-1526            Impact factor:   60.633


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  1 in total

Review 1.  Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.

Authors:  Mark C Field; David Horn; Alan H Fairlamb; Michael A J Ferguson; David W Gray; Kevin D Read; Manu De Rycker; Leah S Torrie; Paul G Wyatt; Susan Wyllie; Ian H Gilbert
Journal:  Nat Rev Microbiol       Date:  2017-02-27       Impact factor: 60.633
  1 in total
  10 in total

1.  Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs.

Authors:  Gustavo A Afanador; Diana R Tomchick; Margaret A Phillips
Journal:  Structure       Date:  2018-09-06       Impact factor: 5.006

2.  Diaryl Ureas as an Antiprotozoal Chemotype.

Authors:  Derek A Leas; Austin G Sanford; Jianbo Wu; Monica Cal; Marcel Kaiser; Sergio Wittlin; Ryan M Hemsley; Elyssa B Darner; LeeAnna M Lui; Paul H Davis; Jonathan L Vennerstrom
Journal:  ACS Infect Dis       Date:  2021-05-10       Impact factor: 5.578

Review 3.  Nucleolar Structure and Function in Trypanosomatid Protozoa.

Authors:  Santiago Martínez-Calvillo; Luis E Florencio-Martínez; Tomás Nepomuceno-Mejía
Journal:  Cells       Date:  2019-05-08       Impact factor: 6.600

4.  A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis.

Authors:  Paula MacGregor; Andrea L Gonzalez-Munoz; Fatoumatta Jobe; Martin C Taylor; Steven Rust; Alan M Sandercock; Olivia J S Macleod; Katrien Van Bocxlaer; Amanda F Francisco; Francois D'Hooge; Arnaud Tiberghien; Conor S Barry; Philip Howard; Matthew K Higgins; Tristan J Vaughan; Ralph Minter; Mark Carrington
Journal:  PLoS Negl Trop Dis       Date:  2019-05-23

5.  Transcription activity contributes to the firing of non-constitutive origins in African trypanosomes helping to maintain robustness in S-phase duration.

Authors:  Marcelo S da Silva; Gustavo R Cayres-Silva; Marcela O Vitarelli; Paula A Marin; Priscila M Hiraiwa; Christiane B Araújo; Bruno B Scholl; Andrea R Ávila; Richard McCulloch; Marcelo S Reis; Maria Carolina Elias
Journal:  Sci Rep       Date:  2019-12-06       Impact factor: 4.379

Review 6.  Sleeping Sickness: A Tale of Two Clocks.

Authors:  Filipa Rijo-Ferreira; Joseph S Takahashi
Journal:  Front Cell Infect Microbiol       Date:  2020-10-02       Impact factor: 5.293

7.  Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice.

Authors:  Iain W McNae; James Kinkead; Divya Malik; Li-Hsuan Yen; Martin K Walker; Chris Swain; Scott P Webster; Nick Gray; Peter M Fernandes; Elmarie Myburgh; Elizabeth A Blackburn; Ryan Ritchie; Carol Austin; Martin A Wear; Adrian J Highton; Andrew J Keats; Antonio Vong; Jacqueline Dornan; Jeremy C Mottram; Paul A M Michels; Simon Pettit; Malcolm D Walkinshaw
Journal:  Nat Commun       Date:  2021-02-16       Impact factor: 14.919

8.  Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition.

Authors:  Pieter C Steketee; Emily A Dickie; James Iremonger; Kathryn Crouch; Edith Paxton; Siddharth Jayaraman; Omar A Alfituri; Georgina Awuah-Mensah; Ryan Ritchie; Achim Schnaufer; Tim Rowan; Harry P de Koning; Catarina Gadelha; Bill Wickstead; Michael P Barrett; Liam J Morrison
Journal:  PLoS Pathog       Date:  2021-07-26       Impact factor: 6.823

Review 9.  Discovery and Genetic Validation of Chemotherapeutic Targets for Chagas' Disease.

Authors:  Juan Felipe Osorio-Méndez; Ana María Cevallos
Journal:  Front Cell Infect Microbiol       Date:  2019-01-07       Impact factor: 5.293

10.  Identification of four unconventional kinetoplastid kinetochore proteins KKT22-25 in Trypanosoma brucei.

Authors:  Olga O Nerusheva; Patryk Ludzia; Bungo Akiyoshi
Journal:  Open Biol       Date:  2019-12-04       Impact factor: 6.411
  10 in total

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