Yasmin Magdi1, Ahmed El-Damen2, Ahmed Mohamed Fathi3, Ahmed Mostafa Abdelaziz4, Mohamed Abd-Elfatah Youssef5, Ahmed Abd-Elmaged Abd-Allah5, Mona Ahmed Elawady6, Mohamed Ahmed Ibrahim4, Yehia Edris4. 1. IVF Laboratory, Al-Yasmeen Fertility and Gynecology Center, Benha, Egypt. Electronic address: yas.magdi@hotmail.com. 2. IVF Laboratory, Nile Badrawi Hospital, Cairo, Egypt. 3. Department of Obstetrics and Gynecology, Faculty of Medicine, Kafrelsheikh University, Kafr El-Sheikh, Egypt. 4. Obstetrics and Gynecology Department, Faculty of Medicine, Benha University, Benha, Egypt. 5. Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt. 6. Department of Community Medicine, Faculty of Medicine, Benha University, Benha, Egypt.
Abstract
OBJECTIVE: To determine whether a freeze-all policy for in vitro human blastocysts improves the ongoing pregnancy rate in patients with recurrent implantation failure (RIF). DESIGN: Prospective cohort study. SETTING: Single private center. PATIENT(S): A total of 171 women with RIF divided into two groups: freeze-all policy group (n = 81) and fresh embryo transfer (ET) group (n = 90). INTERVENTION(S): Freeze-all policy. MAIN OUTCOME MEASURE(S): Ongoing pregnancy rate. RESULT(S): The clinical pregnancy rate (52% vs. 28%; odds ratio [OR] 1.86; 95% confidence interval [CI], 1.29-2.68) and ongoing pregnancy rate (44% vs. 20%; OR 2.2; 95% CI, 1.04-3.45) were statistically significantly higher in the freeze-all group than the fresh ET group, respectively. The implantation rate was also statistically significant (freeze-all group 44.2% vs. fresh ET group 15.8%; OR 2.80; 95% CI, 2.00-3.92). CONCLUSION(S): The freeze-all policy statistically significantly improved the ongoing pregnancy and implantation rates. Thus, a freeze-all policy is likely to be the new key to helping open the black box of RIF. These findings also are useful for further investigating the adverse effect of controlled ovarian stimulation on in vitro fertilization outcomes.
OBJECTIVE: To determine whether a freeze-all policy for in vitro human blastocysts improves the ongoing pregnancy rate in patients with recurrent implantation failure (RIF). DESIGN: Prospective cohort study. SETTING: Single private center. PATIENT(S): A total of 171 women with RIF divided into two groups: freeze-all policy group (n = 81) and fresh embryo transfer (ET) group (n = 90). INTERVENTION(S): Freeze-all policy. MAIN OUTCOME MEASURE(S): Ongoing pregnancy rate. RESULT(S): The clinical pregnancy rate (52% vs. 28%; odds ratio [OR] 1.86; 95% confidence interval [CI], 1.29-2.68) and ongoing pregnancy rate (44% vs. 20%; OR 2.2; 95% CI, 1.04-3.45) were statistically significantly higher in the freeze-all group than the fresh ET group, respectively. The implantation rate was also statistically significant (freeze-all group 44.2% vs. fresh ET group 15.8%; OR 2.80; 95% CI, 2.00-3.92). CONCLUSION(S): The freeze-all policy statistically significantly improved the ongoing pregnancy and implantation rates. Thus, a freeze-all policy is likely to be the new key to helping open the black box of RIF. These findings also are useful for further investigating the adverse effect of controlled ovarian stimulation on in vitro fertilization outcomes.
Authors: Katherine M Johnson; Michele R Hacker; Nina Resetkova; Barbara O'Brien; Anna M Modest Journal: Fertil Steril Date: 2019-02-28 Impact factor: 7.329
Authors: Felipe Dieamant; Laura D Vagnini; Claudia G Petersen; Ana L Mauri; Adriana Renzi; Bruna Petersen; Mariana C Mattila; Andreia Nicoletti; Joao Batista A Oliveira; Ricardo Baruffi; Jose G Franco Journal: JBRA Assist Reprod Date: 2019-08-22