Peng Jin1, Maarten C C M Hulshof2, Niek van Wieringen2, Arjan Bel2, Tanja Alderliesten2. 1. Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, The Netherlands. Electronic address: p.jin@amc.uva.nl. 2. Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, The Netherlands.
Abstract
PURPOSE: To investigate the interfractional variability of respiration-induced esophageal tumor motion using fiducial markers and four-dimensional cone-beam computed tomography (4D-CBCT) and assess if a 4D-CT is sufficient for predicting the motion during the treatment. MATERIALS AND METHODS: Twenty-four patients with 63 markers visible in the retrospectively reconstructed 4D-CBCTs were included. For each marker, we calculated the amplitude and trajectory of the respiration-induced motion. Possible time trends of the amplitude over the treatment course and the interfractional variability of amplitudes and trajectory shapes were assessed. Further, the amplitudes measured in the 4D-CT were compared to those in the 4D-CBCTs. RESULTS: The amplitude was largest in the cranial-caudal direction of the distal esophagus (mean: 7.1mm) and proximal stomach (mean: 7.8mm). No time trend was observed in the amplitude over the treatment course. The interfractional variability of amplitudes and trajectory shapes was limited (mean: ≤1.4mm). Moreover, small and insignificant deviation was found between the amplitudes quantified in the 4D-CT and in the 4D-CBCT (mean absolute difference: ≤1.0mm). CONCLUSIONS: The limited interfractional variability of amplitudes and trajectory shapes and small amplitude difference between 4D-CT-based and 4D-CBCT-based measurements imply that a single 4D-CT would be sufficient for predicting the respiration-induced esophageal tumor motion during the treatment course.
PURPOSE: To investigate the interfractional variability of respiration-induced esophageal tumor motion using fiducial markers and four-dimensional cone-beam computed tomography (4D-CBCT) and assess if a 4D-CT is sufficient for predicting the motion during the treatment. MATERIALS AND METHODS: Twenty-four patients with 63 markers visible in the retrospectively reconstructed 4D-CBCTs were included. For each marker, we calculated the amplitude and trajectory of the respiration-induced motion. Possible time trends of the amplitude over the treatment course and the interfractional variability of amplitudes and trajectory shapes were assessed. Further, the amplitudes measured in the 4D-CT were compared to those in the 4D-CBCTs. RESULTS: The amplitude was largest in the cranial-caudal direction of the distal esophagus (mean: 7.1mm) and proximal stomach (mean: 7.8mm). No time trend was observed in the amplitude over the treatment course. The interfractional variability of amplitudes and trajectory shapes was limited (mean: ≤1.4mm). Moreover, small and insignificant deviation was found between the amplitudes quantified in the 4D-CT and in the 4D-CBCT (mean absolute difference: ≤1.0mm). CONCLUSIONS: The limited interfractional variability of amplitudes and trajectory shapes and small amplitude difference between 4D-CT-based and 4D-CBCT-based measurements imply that a single 4D-CT would be sufficient for predicting the respiration-induced esophageal tumor motion during the treatment course.
Authors: Melissa Thomas; Robin De Roover; Schalk van der Merwe; Maarten Lambrecht; Gilles Defraene; Karin Haustermans Journal: Clin Transl Radiat Oncol Date: 2020-11-05
Authors: M R Boekhoff; R Bouwmans; P A H Doornaert; M P W Intven; J J W Lagendijk; A L H M W van Lier; M J A Rasing; S van de Ven; G J Meijer; S Mook Journal: Clin Transl Radiat Oncol Date: 2022-03-17
Authors: Sophie C Huijskens; Irma W E M van Dijk; Jorrit Visser; Brian V Balgobind; Coen R N Rasch; Tanja Alderliesten; Arjan Bel Journal: Radiat Oncol Date: 2018-10-11 Impact factor: 3.481