| Literature DB >> 28577908 |
Surenmandakh Gombodorj1, Ming-Hua Yang1, Zhi-Chun Shang1, Rui-Huan Liu1, Tian-Xiao Li1, Guo-Ping Yin1, Ling-Yi Kong2.
Abstract
Nine new phenalenone derivatives (1-9), along with two known analogues (10-11) have been isolated from the solid cultures of an endophytic fungus Aspergillus sp. which was obtained from Pinellia ternate. Their structures were established through interpretations of spectroscopic evidence, and some of their absolute configurations were determined by electronic circular dichroism (ECD) and Mo2(OCOCH3)4 induced ECD. All of the phenalenones are unusual acyclic diterpenoid adducts, which are diversely oxidized and partly epoxidized to form different heterocycles. In addition, compound 10 exhibited significant antimicrobial activity against Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis with MIC50 values of 1.87, 2.77, and 4.80μg/mL, respectively.Entities:
Keywords: Acyclic diterpenoid adducts; Antibacterial activities; Aspergillus sp.; Ethyl ethanoate (PubChem CID: 8857); Methanol (PubChem CID: 887); Methyl cyanide (PubChem CID: 6342); Methylene chloride (PubChem CID: 6344); Phenalenones
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Year: 2017 PMID： 28577908 DOI： 10.1016/j.fitote.2017.05.014
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882