Literature DB >> 28577740

Oxygen sensors as therapeutic targets in kidney disease.

Volker H Haase1.   

Abstract

Hypoxia is a common clinical problem that has profound effects on renal homeostasis. Prolyl-4-hydroxylases PHD1, 2 and 3 function as oxygen sensors and control the activity of hypoxia-inducible factor (HIF), an oxygen-sensitive transcription factor that regulates a multitude of hypoxia responses, which help cells and tissues to adapt to low oxygen environments. This review provides an overview of the molecular mechanisms that govern these hypoxia responses and discusses clinical experience with compounds that inhibit prolyl-4-hydroxylases to harness HIF responses for therapy in nephrology.
Copyright © 2017 Société francophone de néphrologie, dialyse et transplantation. Published by Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Chronic kidney disease; Erythropoietin; Hypoxia; Hypoxia-inducible factor; Prolyl-4-hydroxylase

Mesh：

Substances：

Year:  2017        PMID： 28577740     DOI： 10.1016/j.nephro.2017.01.015

Source DB:  PubMed          Journal:  Nephrol Ther        ISSN： 1769-7255            Impact factor:   0.722


  5 in total

1.  Effects of PHD and HSP90 on erythropoietin production in yak (Bos grunniens) renal interstitial fibroblast-like cells under hypoxia.

Authors:  Yan Cui; Hui Li; Si-Jiu Yu; Seth Yaw Afedo; Xue-Feng Bai
Journal:  J Mol Histol       Date:  2022-01-27       Impact factor: 2.611

2.  Dysregulation of the sensory and regulatory pathways controlling cellular iron metabolism in unilateral obstructive nephropathy.

Authors:  James A Votava; Shannon R Reese; Kathryn M Deck; Christopher P Nizzi; Sheila A Anderson; Arjang Djamali; Richard S Eisenstein
Journal:  Am J Physiol Renal Physiol       Date:  2021-11-29

3.  Activation of the Hypoxia-Inducible Factor Pathway Inhibits Epithelial Sodium Channel-Mediated Sodium Transport in Collecting Duct Principal Cells.

Authors:  Eva Dizin; Valerie Olivier; Isabelle Roth; Ali Sassi; Grégoire Arnoux; Suresh Ramakrishnan; Sandrine Morel; Brenda Kwak; Johannes Loffing; Edith Hummler; Roland H. Wenger; Ian Frew; Eric Feraille
Journal:  J Am Soc Nephrol       Date:  2021-10-06       Impact factor: 10.121

4.  Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes.

Authors:  Xiaowei Zheng; Sampath Narayanan; Cheng Xu; Fredrik Palm; Sergiu-Bogdan Catrina; Sofie Eliasson Angelstig; Jacob Grünler; Allan Zhao; Alessandro Di Toro; Luciano Bernardi; Massimiliano Mazzone; Peter Carmeliet; Marianna Del Sole; Giancarlo Solaini; Elisabete A Forsberg; Ao Zhang; Kerstin Brismar; Tomas A Schiffer; Neda Rajamand Ekberg; Ileana Ruxandra Botusan
Journal:  Elife       Date:  2022-02-15       Impact factor: 8.140

5.  Inhibition of oxygen-sensing prolyl hydroxylases increases lipid accumulation in human primary tubular epithelial cells without inducing ER stress.

Authors:  Gunnar Schley; Steffen Grampp; Margarete Goppelt-Struebe
Journal:  Cell Tissue Res       Date:  2020-03-18       Impact factor: 5.249
  5 in total

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