Literature DB >> 28577430

Posttranslational modifications of neuroligins regulate neuronal and glial signaling.

Jaehoon Jeong1, Jeremiah D Paskus2, Katherine W Roche3.   

Abstract

This review covers the dynamic regulation of neuroligin isoforms, focusing on posttranslational events including phosphorylation, glycosylation and activity-dependent cleavage. There is a growing literature on how phosphorylation confers an isoform-specific level of modulation affecting a variety of protein interactions. In addition, recent studies describe activity-dependent proteolytic cleavage of neuroligins, revealing a broader role for neuroligins than just synaptic 'glue'. Interesting new research implicates the cleaved extracellular fragments of neuroligins in promoting glioma. These reports on cell signaling mediated by the cleavage products of neuroligins suggest novel and important roles for neuroligins in neuro-glial signaling. Published by Elsevier Ltd.

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Year:  2017        PMID： 28577430      PMCID： PMC5554730          DOI： 10.1016/j.conb.2017.05.017

Source DB:  PubMed          Journal:  Curr Opin Neurobiol        ISSN： 0959-4388            Impact factor:   6.627


  53 in total

Review 1.  Synaptic adhesion molecules.

Authors:  Masahito Yamagata; Joshua R Sanes; Joshua A Weiner
Journal:  Curr Opin Cell Biol       Date:  2003-10       Impact factor: 8.382

2.  Crystal structure of the extracellular cholinesterase-like domain from neuroligin-2.

Authors:  Jesko Koehnke; Xiangshu Jin; Elaine C Budreck; Shoshana Posy; Peter Scheiffele; Barry Honig; Lawrence Shapiro
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-04       Impact factor: 11.205

3.  Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.

Authors:  Mrinalini Hoon; Tolga Soykan; Björn Falkenburger; Matthieu Hammer; Annarita Patrizi; Karl-Friedrich Schmidt; Marco Sassoè-Pognetto; Siegrid Löwel; Tobias Moser; Holger Taschenberger; Nils Brose; Frédérique Varoqueaux
Journal:  Proc Natl Acad Sci U S A       Date:  2011-01-31       Impact factor: 11.205

4.  Axo-glial communication through neurexin-neuroligin signaling regulates myelination and oligodendrocyte differentiation.

Authors:  Dustin T Proctor; Stephanie C Stotz; Lucas O M Scott; Cristiane L R de la Hoz; Kelvin W C Poon; Peter K Stys; Michael A Colicos
Journal:  Glia       Date:  2015-06-29       Impact factor: 7.452

5.  Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism.

Authors:  Alexander A Chubykin; Xinran Liu; Davide Comoletti; Igor Tsigelny; Palmer Taylor; Thomas C Südhof
Journal:  J Biol Chem       Date:  2005-03-29       Impact factor: 5.157

6.  Autism-associated mutation inhibits protein kinase C-mediated neuroligin-4X enhancement of excitatory synapses.

Authors:  Michael A Bemben; Quynh-Anh Nguyen; Tongguang Wang; Yan Li; Roger A Nicoll; Katherine W Roche
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-09       Impact factor: 11.205

7.  Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin.

Authors:  Alexandros Poulopoulos; Gayane Aramuni; Guido Meyer; Tolga Soykan; Mrinalini Hoon; Theofilos Papadopoulos; Mingyue Zhang; Ingo Paarmann; Céline Fuchs; Kirsten Harvey; Peter Jedlicka; Stephan W Schwarzacher; Heinrich Betz; Robert J Harvey; Nils Brose; Weiqi Zhang; Frédérique Varoqueaux
Journal:  Neuron       Date:  2009-09-10       Impact factor: 17.173

8.  Transsynaptic signaling by activity-dependent cleavage of neuroligin-1.

Authors:  Rui T Peixoto; Portia A Kunz; Hyungbae Kwon; Angela M Mabb; Bernardo L Sabatini; Benjamin D Philpot; Michael D Ehlers
Journal:  Neuron       Date:  2012-10-17       Impact factor: 17.173

9.  Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta.

Authors:  Davide Comoletti; Robyn Flynn; Lori L Jennings; Alexander Chubykin; Takehito Matsumura; Hana Hasegawa; Thomas C Südhof; Palmer Taylor
Journal:  J Biol Chem       Date:  2003-09-30       Impact factor: 5.157

10.  Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

Authors:  Ailan Guo; Hongbo Gu; Jing Zhou; Daniel Mulhern; Yi Wang; Kimberly A Lee; Vicky Yang; Mike Aguiar; Jon Kornhauser; Xiaoying Jia; Jianmin Ren; Sean A Beausoleil; Jeffrey C Silva; Vidyasiri Vemulapalli; Mark T Bedford; Michael J Comb
Journal:  Mol Cell Proteomics       Date:  2013-10-15       Impact factor: 5.911
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  14 in total

1.  An Autism-Associated Mutation Impairs Neuroligin-4 Glycosylation and Enhances Excitatory Synaptic Transmission in Human Neurons.

Authors:  Thomas P Cast; Daniel J Boesch; Kim Smyth; Alisa E Shaw; Michael Ghebrial; Soham Chanda
Journal:  J Neurosci       Date:  2020-12-02       Impact factor: 6.167

2.  PSD-95 binding dynamically regulates NLGN1 trafficking and function.

Authors:  Jaehoon Jeong; Saurabh Pandey; Yan Li; John D Badger; Wei Lu; Katherine W Roche
Journal:  Proc Natl Acad Sci U S A       Date:  2019-05-28       Impact factor: 11.205

3.  A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.

Authors:  Thien A Nguyen; Kunwei Wu; Saurabh Pandey; Alexander W Lehr; Yan Li; Michael A Bemben; John D Badger; Julie L Lauzon; Tongguang Wang; Kareem A Zaghloul; Audrey Thurm; Mahim Jain; Wei Lu; Katherine W Roche
Journal:  Neuron       Date:  2020-04-02       Impact factor: 17.173

4.  Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylation.

Authors:  Mathieu Letellier; Matthieu Lagardère; Béatrice Tessier; Harald Janovjak; Olivier Thoumine
Journal:  Elife       Date:  2020-04-23       Impact factor: 8.140

5.  Slitrk2 controls excitatory synapse development via PDZ-mediated protein interactions.

Authors:  Kyung Ah Han; Jinhu Kim; Hyeonho Kim; Dongwook Kim; Dongseok Lim; Jaewon Ko; Ji Won Um
Journal:  Sci Rep       Date:  2019-11-19       Impact factor: 4.379

Review 6.  Ubiquitin and Ubiquitin-Like Proteins in the Critical Equilibrium between Synapse Physiology and Intellectual Disability.

Authors:  Alessandra Folci; Filippo Mirabella; Matteo Fossati
Journal:  eNeuro       Date:  2020-08-26

Review 7.  Proteomic insights into synaptic signaling in the brain: the past, present and future.

Authors:  Yalan Xu; Xiuyue Song; Dong Wang; Yin Wang; Peifeng Li; Jing Li
Journal:  Mol Brain       Date:  2021-02-17       Impact factor: 4.041

8.  Coordination of olfactory receptor choice with guidance receptor expression and function in olfactory sensory neurons.

Authors:  Puneet Dang; Stephen A Fisher; Derek J Stefanik; Junhyong Kim; Jonathan A Raper
Journal:  PLoS Genet       Date:  2018-01-31       Impact factor: 5.917

9.  Elevated O-GlcNAcylation induces an antidepressant-like phenotype and decreased inhibitory transmission in medial prefrontal cortex.

Authors:  Yoonjeong Cho; Hongik Hwang; Md Ataur Rahman; ChiHye Chung; Hyewhon Rhim
Journal:  Sci Rep       Date:  2020-04-24       Impact factor: 4.379

10.  Alternative splicing at neuroligin site A regulates glycan interaction and synaptogenic activity.

Authors:  Shinichiro Oku; Huijuan Feng; Steven Connor; Andrea Toledo; Peng Zhang; Yue Zhang; Olivier Thoumine; Chaolin Zhang; Ann Marie Craig
Journal:  Elife       Date:  2020-09-11       Impact factor: 8.140
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