Literature DB >> 28576914

Do not treat the numbers: lithium toxicity.

Peter Foulser1, Yasmin Abbasi1, Anand Mathilakath1, Ramin Nilforooshan1.   

Abstract

We describe the case of a 62-year-old man with a history of bipolar disorder, previously stable on lithium for over 20 years, who presented with a manic relapse and signs of lithium toxicity in the form of a coarse tremor. Serum lithium levels were in the normal range, and the patient had stage 3 chronic kidney disease. He was admitted for treatment under Section 2 of the Mental Health Act, and after stopping lithium was started on olanzapine. Signs of lithium toxicity improved after withdrawal of lithium. This case highlights the need to treat normal serum lithium levels with caution in patients showing signs of clinical lithium toxicity. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Entities:  

Keywords:  Bipolar I disorder; Contraindications and precautions; Drugs: psychiatry; Psychiatry (drugs and medicines)

Mesh:

Substances:

Year:  2017        PMID: 28576914      PMCID: PMC5534930          DOI: 10.1136/bcr-2017-220079

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  8 in total

1.  Lithium toxicity: a double-edged sword.

Authors:  M P Alexander; Y M K Farag; B V Mittal; H G Rennke; A K Singh
Journal:  Kidney Int       Date:  2007-10-17       Impact factor: 10.612

Review 2.  Lithium toxicity profile: a systematic review and meta-analysis.

Authors:  Rebecca F McKnight; Marc Adida; Katie Budge; Sarah Stockton; Guy M Goodwin; John R Geddes
Journal:  Lancet       Date:  2012-01-20       Impact factor: 79.321

3.  Reconsidering risk factors for renal dysfunction in lithium-treated patients.

Authors:  Alberto Bocchetta
Journal:  Evid Based Ment Health       Date:  2016-08-31

Review 4.  Clinical manifestations and management of acute lithium intoxication.

Authors:  M D Okusa; L J Crystal
Journal:  Am J Med       Date:  1994-10       Impact factor: 4.965

5.  Cellular mechanism of lithium-induced nephrogenic diabetes insipidus in rats.

Authors:  M Yamaki; E Kusano; T Tetsuka; S Takeda; S Homma; N Murayama; Y Asano
Journal:  Am J Physiol       Date:  1991-09

6.  Long-term effect of lithium maintenance therapy on estimated glomerular filtration rate in patients with affective disorders: a population-based cohort study.

Authors:  Stefan Clos; Petra Rauchhaus; Alison Severn; Lynda Cochrane; Peter T Donnan
Journal:  Lancet Psychiatry       Date:  2015-10-06       Impact factor: 27.083

7.  Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla.

Authors:  D Marples; S Christensen; E I Christensen; P D Ottosen; S Nielsen
Journal:  J Clin Invest       Date:  1995-04       Impact factor: 14.808

Review 8.  Lithium Poisoning.

Authors:  Jonathan Baird-Gunning; Tom Lea-Henry; Lotte C G Hoegberg; Sophie Gosselin; Darren M Roberts
Journal:  J Intensive Care Med       Date:  2016-08-11       Impact factor: 3.510

  8 in total

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