Xiaoxian Li1, Jing Yang2, Uma Krishnamurti3, Lei Huo4, Kevin C Ward2, Ruth O'Regan5, Limin Peng2. 1. Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA. Electronic address: xli40@emory.edu. 2. Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA. 3. Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA. 4. Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX. 5. Department of Medicine, University of Wisconsin, Madison, WI.
Abstract
INTRODUCTION: Male breast carcinoma (MBC) is treated similarly to female breast carcinoma (FBC), and similar survival rates for both have been assumed. We analyzed prognostic and clinicopathologic features of MBC to determine whether MBC subtypes differ from FBC subtypes. PATIENTS AND METHODS: We reviewed data for 172,847 FBC and 1442 MBC patients from 2010 to 2012 from the National Cancer Institute Surveillance, Epidemiology, and End Results database. Carcinomas were subtyped according to hormone receptor (HR) and HER2 status as HR-positive (HR+)/HER2-, HR+/HER2+, HR-/HER2+, and HR-/HER2-. RESULTS: The overall incidence of MBC in all breast carcinoma cases was 0.8%. MBC was more frequently HR+/HER2- than was FBC (78.3% vs. 67.4%) and less frequently HR-/HER2- (2.1% vs. 10.9%). More MBC was staged as III or IV (24.9% vs. 17.2%). MBC had significantly worse overall survival (OS) than FBC (P < .0001). After adjustment for age, ethnicity, and tumor grade, stage I and II MBC had significantly worse OS time than stage-matched FBC (P = .0011 for stage I, P = .0229 for stage II). When stage- and subtype-matched patients were compared, MBC had significantly worse OS than FBC for stage I overall, for substages IA and IIB HR+/HER2- carcinoma, and for stage III HR+/HER2+ carcinoma. Furthermore, MBC patients with HR+/HER2- T1aN0 carcinomas had worse OS than did FBC patients. CONCLUSION: Patients with MBC have worse survival than patients with FBC, especially for early-stage HR+ breast cancers. More studies are needed optimize treatment for MBC.
INTRODUCTION:Male breast carcinoma (MBC) is treated similarly to female breast carcinoma (FBC), and similar survival rates for both have been assumed. We analyzed prognostic and clinicopathologic features of MBC to determine whether MBC subtypes differ from FBC subtypes. PATIENTS AND METHODS: We reviewed data for 172,847 FBC and 1442 MBCpatients from 2010 to 2012 from the National Cancer Institute Surveillance, Epidemiology, and End Results database. Carcinomas were subtyped according to hormone receptor (HR) and HER2 status as HR-positive (HR+)/HER2-, HR+/HER2+, HR-/HER2+, and HR-/HER2-. RESULTS: The overall incidence of MBC in all breast carcinoma cases was 0.8%. MBC was more frequently HR+/HER2- than was FBC (78.3% vs. 67.4%) and less frequently HR-/HER2- (2.1% vs. 10.9%). More MBC was staged as III or IV (24.9% vs. 17.2%). MBC had significantly worse overall survival (OS) than FBC (P < .0001). After adjustment for age, ethnicity, and tumor grade, stage I and II MBC had significantly worse OS time than stage-matched FBC (P = .0011 for stage I, P = .0229 for stage II). When stage- and subtype-matched patients were compared, MBC had significantly worse OS than FBC for stage I overall, for substages IA and IIB HR+/HER2- carcinoma, and for stage III HR+/HER2+ carcinoma. Furthermore, MBCpatients with HR+/HER2- T1aN0 carcinomas had worse OS than did FBC patients. CONCLUSION:Patients with MBC have worse survival than patients with FBC, especially for early-stage HR+ breast cancers. More studies are needed optimize treatment for MBC.
Authors: Thi Truc Anh Nguyen; Lauren M Postlewait; Chao Zhang; Jane L Meisel; Ruth O'Regan; Sunil Badve; Kevin Kalinsky; Xiaoxian Li Journal: Breast Cancer Res Treat Date: 2022-01-27 Impact factor: 4.872
Authors: Hongxiao Li; Jigang Wang; Zaibo Li; Melad Dababneh; Fusheng Wang; Peng Zhao; Geoffrey H Smith; George Teodoro; Meijie Li; Jun Kong; Xiaoxian Li Journal: Front Med (Lausanne) Date: 2022-06-14