Literature DB >> 28576601

Linc-ing the Noncoding Genome to Heart Function: Beating Hypertrophy.

Shambhabi Chatterjee1, Christian Bär2, Thomas Thum3.   

Abstract

The principal event of aberrant gene expression occurs in numerous disorders and syndromes, including heart failure. LncRNAs may constitute powerful treatment targets because they intensively interact with their genetic environment, as they are important regulators of genetic networks. Recent advances on the functional roles of lncRNAs in cardiac hypertrophy are expected to usher improved therapeutic strategies.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  cardiac hypertrophy; cardiovascular disease; diagnostics; long noncoding RNA; ncRNA biomarker; therapeutics

Mesh：

Substances：

Year:  2017        PMID： 28576601     DOI： 10.1016/j.molmed.2017.05.007

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  5 in total

1.  The long non-coding RNA NRON promotes the development of cardiac hypertrophy in the murine heart.

Authors:  Jeannine Hoepfner; Julia Leonardy; Dongchao Lu; Kevin Schmidt; Hannah J Hunkler; Sinje Biß; Ariana Foinquinos; Ke Xiao; Kumarswamy Regalla; Deepak Ramanujam; Stefan Engelhardt; Christian Bär; Thomas Thum
Journal:  Mol Ther       Date:  2021-11-29       Impact factor: 11.454

Review 2.  The noncoding-RNA landscape in cardiovascular health and disease.

Authors:  Vittoria Di Mauro; Maria Barandalla-Sobrados; Daniele Catalucci
Journal:  Noncoding RNA Res       Date:  2018-02-09

Review 3.  The Dark That Matters: Long Non-coding RNAs as Master Regulators of Cellular Metabolism in Non-communicable Diseases.

Authors:  Alessia Mongelli; Fabio Martelli; Antonella Farsetti; Carlo Gaetano
Journal:  Front Physiol       Date:  2019-05-22       Impact factor: 4.566

Review 4.  The function of LncRNA-H19 in cardiac hypertrophy.

Authors:  Wenhua Su; Qian Huo; Hao Wu; Lulin Wang; Xiaoxue Ding; Liwen Liang; Liang Zhou; Yan Zhao; Juhua Dan; Hong Zhang
Journal:  Cell Biosci       Date:  2021-08-03       Impact factor: 7.133

5.  Targeting muscle-enriched long non-coding RNA H19 reverses pathological cardiac hypertrophy.

Authors:  Janika Viereck; Anne Bührke; Ariana Foinquinos; Shambhabi Chatterjee; Jan A Kleeberger; Ke Xiao; Heike Janssen-Peters; Sandor Batkai; Deepak Ramanujam; Theresia Kraft; Serghei Cebotari; Faikah Gueler; Andreas M Beyer; Jessica Schmitz; Jan H Bräsen; Jan D Schmitto; Mariann Gyöngyösi; Alexandra Löser; Marc N Hirt; Thomas Eschenhagen; Stefan Engelhardt; Christian Bär; Thomas Thum
Journal:  Eur Heart J       Date:  2020-09-21       Impact factor: 29.983
  5 in total

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