Literature DB >> 28576169

Urokinase Plasminogen Activator Receptor-PET with 68Ga-NOTA-AE105: First Clinical Experience with a Novel PET Ligand.

Dorthe Skovgaard1, Morten Persson2, Andreas Kjaer3.   

Abstract

Urokinase plasminogen activator receptor (uPAR) is a key component in proteolysis and extracellular matrix degradation during cancer invasion and metastasis. uPAR overexpression is an important biomarker for aggressiveness in several solid tumors and provides independent clinical information. A recent major breakthrough was obtained with human translation of uPAR PET using 68Ga-NOTA-AE105. Clinical results are encouraging and several large-scale clinical trials are now ongoing. This review focuses on uPAR PET with 68Ga-NOTA-AE105 as a new broadly applicable diagnostic and prognostic imaging biomarker in cancer.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Breast cancer; Invasiveness; Molecular imaging; Oncology; PET; Prognostication; Prostate cancer; Theranostics

Mesh：

Substances：

Year:  2017        PMID： 28576169     DOI： 10.1016/j.cpet.2017.02.003

Source DB:  PubMed          Journal:  PET Clin        ISSN： 1556-8598


  6 in total

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2.  Prognostic Value of Urokinase-Type Plasminogen Activator Receptor PET/CT in Head and Neck Squamous Cell Carcinomas and Comparison with 18F-FDG PET/CT: A Single-Center Prospective Study.

Authors:  Louise M Risør; Malene M Clausen; Zaza Ujmajuridze; Mohammed Farhadi; Kim F Andersen; Annika Loft; Jeppe Friborg; Andreas Kjaer
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Review 3.  A Comprehensive Review of Non-Covalent Radiofluorination Approaches Using Aluminum [18F]fluoride: Will [18F]AlF Replace 68Ga for Metal Chelate Labeling?

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Journal:  Molecules       Date:  2019-08-07       Impact factor: 4.411

Review 4.  Radiolabelled Peptides for Positron Emission Tomography and Endoradiotherapy in Oncology.

Authors:  Christine Rangger; Roland Haubner
Journal:  Pharmaceuticals (Basel)       Date:  2020-01-30

5.  Microfluidic-Assisted Preparation of Targeted pH-Responsive Polymeric Micelles Improves Gemcitabine Effectiveness in PDAC: In Vitro Insights.

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Journal:  Cancers (Basel)       Date:  2021-12-21       Impact factor: 6.639

Review 6.  Therapeutics targeting the fibrinolytic system.

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Journal:  Exp Mol Med       Date:  2020-03-09       Impact factor: 8.718
  6 in total

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