DERMAL ADIPOSE TISSUE IN HAIR FOLLICLE CYCLING: POSSIBLE APPLICATIONS IN ALOPECIA?

Cross-talk between the hair follicles (HFs) in different stages of their cycling and adjacent adipose tissue is a new important topic which is of both theoretical and practical interest. Objective - to analyze available data on possible interrelationship of dermal adipose tissue and hair follicle cycling. Experimental results obtained in rodents clearly demonstrate that HFs cycling is connected to adjacent dermal adipose tissue. Recently uncovered adipocyte-myofibroblast transition can be significantly involved in miniaturization of HFs and be an important pathophysiological step in androgenetic alopecia. Improvement of adipogenic environment of HFs can be important both in treatment of alopecia and in surgical hair restoration procedures.