Enzymatically activated reduction-caged SERS reporters for versatile bioassays.

Here we report a facile strategy for activating reduction caged Raman reporters for surface-enhanced Raman scattering (SERS) with peroxidases. After selecting suitable caged reporters, versatile bioassays were developed. First, the bioassays for bioactive small molecules were developed. Then, the immunoassay was developed for C reactive protein (CRP), a biomarker for cardiovascular diseases.