Literature DB >> 28574056

The DUB blade goes snicker-snack: Novel ubiquitin cleavage by a Legionella effector protein.

Judith A Ronau1, Mark Hochstrasser1,2.   

Abstract

Recently, a Legionella pneumophila effector protein was shown to have an unprecedented ATP-independent ubiquitin ligase activity that couples phosphoribosylated ubiquitin (PR-Ub) to serine residues of host proteins. A new study published in Cell Research by Qiu et al. reveals that another Legionella effector protein, SidJ, catalyzes deubiquitination of PR-Ub by cleavage of the substrate-linked phosphodiester bond.

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Year:  2017        PMID： 28574056      PMCID： PMC5518992          DOI： 10.1038/cr.2017.80

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  11 in total

1.  Basic Medical Research Award. The ubiquitin system.

Authors:  A Hershko; A Ciechanover; A Varshavsky
Journal:  Nat Med       Date:  2000-10       Impact factor: 53.440

Review 2.  Mechanism and function of deubiquitinating enzymes.

Authors:  Alexander Y Amerik; Mark Hochstrasser
Journal:  Biochim Biophys Acta       Date:  2004-11-29

Review 3.  Ubiquitination of substrates by esterification.

Authors:  Xiaoli Wang; Roger A Herr; Ted H Hansen
Journal:  Traffic       Date:  2011-09-13       Impact factor: 6.215

4.  Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination.

Authors:  Sagar Bhogaraju; Sissy Kalayil; Yaobin Liu; Florian Bonn; Thomas Colby; Ivan Matic; Ivan Dikic
Journal:  Cell       Date:  2016-12-01       Impact factor: 41.582

5.  Structural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitination.

Authors:  Michael J Sheedlo; Jiazhang Qiu; Yunhao Tan; Lake N Paul; Zhao-Qing Luo; Chittaranjan Das
Journal:  Proc Natl Acad Sci U S A       Date:  2015-11-23       Impact factor: 11.205

6.  Spatiotemporal regulation of a Legionella pneumophila T4SS substrate by the metaeffector SidJ.

Authors:  Kwang Cheol Jeong; Jessica A Sexton; Joseph P Vogel
Journal:  PLoS Pathog       Date:  2015-03-16       Impact factor: 6.823

Review 7.  Bacteria-host relationship: ubiquitin ligases as weapons of invasion.

Authors:  Timurs Maculins; Evgenij Fiskin; Sagar Bhogaraju; Ivan Dikic
Journal:  Cell Res       Date:  2016-03-11       Impact factor: 25.617

Review 8.  Substrate specificity of the ubiquitin and Ubl proteases.

Authors:  Judith A Ronau; John F Beckmann; Mark Hochstrasser
Journal:  Cell Res       Date:  2016-03-25       Impact factor: 25.617

9.  A unique deubiquitinase that deconjugates phosphoribosyl-linked protein ubiquitination.

Authors:  Jiazhang Qiu; Kaiwen Yu; Xiaowen Fei; Yao Liu; Ernesto S Nakayasu; Paul D Piehowski; Jared B Shaw; Kedar Puvar; Chittaranjan Das; Xiaoyun Liu; Zhao-Qing Luo
Journal:  Cell Res       Date:  2017-05-12       Impact factor: 25.617

10.  Ubiquitination independent of E1 and E2 enzymes by bacterial effectors.

Authors:  Jiazhang Qiu; Michael J Sheedlo; Kaiwen Yu; Yunhao Tan; Ernesto S Nakayasu; Chittaranjan Das; Xiaoyun Liu; Zhao-Qing Luo
Journal:  Nature       Date:  2016-04-06       Impact factor: 49.962
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  3 in total

Review 1.  Targeting ADP-ribosylation as an antimicrobial strategy.

Authors:  Giuliana Catara; Annunziata Corteggio; Carmen Valente; Giovanna Grimaldi; Luca Palazzo
Journal:  Biochem Pharmacol       Date:  2019-06-06       Impact factor: 5.858

2.  DUB esterase activity further decodes ubiquitin's enigma.

Authors:  Benedikt M Kessler
Journal:  Proc Natl Acad Sci U S A       Date:  2021-02-09       Impact factor: 11.205

Review 3.  Hijacking of the Host Ubiquitin Network by Legionella pneumophila.

Authors:  Jiazhang Qiu; Zhao-Qing Luo
Journal:  Front Cell Infect Microbiol       Date:  2017-12-05       Impact factor: 5.293
  3 in total

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