Xiaofeng Meng1, Baozhong Shi2. 1. Department of Neurosurgery, First Affiliated Hospital, Henan University of Science & Technology, No. 36 Tongji Street, Luonan New District, Luoyang, 471003, Henan, People's Republic of China. 2. Department of Neurosurgery, First Affiliated Hospital, Henan University of Science & Technology, No. 36 Tongji Street, Luonan New District, Luoyang, 471003, Henan, People's Republic of China. shibaozhongmed@yeah.net.
Abstract
OBJECTIVES: To investigate the roles of miR-215 in high-grade glioma and to clarify the regulation of retinoblastoma 1 (RB1) by miR-215. RESULTS: miR-215 is frequently up-regulated in high-grade glioma tissues. Increased miR-215 expression is significantly associated with World Health Organization grade (P < 0.01) tumor size (P < 0.05) and poor prognosis (P < 0.01). Over-expression of miR-215 promoted cell proliferation and knockdown of miR-215 inhibited cell proliferation in vitro. RB1 was identified as a direct and functional target of miR-215. RB1 is generally down-regulated in glioma tissues and its expression inversely correlated with miR-215, which is up-regulated in high-grade glioma tissues, and its expression was negatively correlated with miR-215. CONCLUSIONS: The new miR-215/RB1 axis provides new insights into the molecular mechanism and treatment for glioma.
OBJECTIVES: To investigate the roles of miR-215 in high-grade glioma and to clarify the regulation of retinoblastoma 1 (RB1) by miR-215. RESULTS:miR-215 is frequently up-regulated in high-grade glioma tissues. Increased miR-215 expression is significantly associated with World Health Organization grade (P < 0.01) tumor size (P < 0.05) and poor prognosis (P < 0.01). Over-expression of miR-215 promoted cell proliferation and knockdown of miR-215 inhibited cell proliferation in vitro. RB1 was identified as a direct and functional target of miR-215. RB1 is generally down-regulated in glioma tissues and its expression inversely correlated with miR-215, which is up-regulated in high-grade glioma tissues, and its expression was negatively correlated with miR-215. CONCLUSIONS: The new miR-215/RB1 axis provides new insights into the molecular mechanism and treatment for glioma.