Literature DB >> 28573430

Critical effects of epigenetic regulation in pulmonary arterial hypertension.

Dewei Chen1,2, Wenxiang Gao1,2, Shouxian Wang1,2, Bing Ni3,4, Yuqi Gao5,6.   

Abstract

Pulmonary arterial hypertension (PAH) is characterized by persistent pulmonary vasoconstriction and pulmonary vascular remodeling. The pathogenic mechanisms of PAH remain to be fully clarified and measures of effective prevention are lacking. Recent studies; however, have indicated that epigenetic processes may exert pivotal influences on PAH pathogenesis. In this review, we summarize the latest research findings regarding epigenetic regulation in PAH, focusing on the roles of non-coding RNAs, histone modifications, ATP-dependent chromatin remodeling and DNA methylation, and discuss the potential of epigenetic-based therapies for PAH.

Entities:  

Keywords:  Epigenetic; HDACs; PAECs; PASMCs; Pulmonary arterial hypertension; lncRNAs; miRNAs

Mesh：

Substances：

Year:  2017        PMID： 28573430     DOI： 10.1007/s00018-017-2551-8

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  56 in total

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Authors:  Gengze Wu; Jin Cai; Yu Han; Jinghai Chen; Zhan-Peng Huang; Caiyu Chen; Yue Cai; Hefei Huang; Yujia Yang; Yukai Liu; Zaicheng Xu; Duofen He; Xiaoqun Zhang; Xiaoyun Hu; Luca Pinello; Dan Zhong; Fengtian He; Guo-Cheng Yuan; Da-Zhi Wang; Chunyu Zeng
Journal:  Circulation       Date:  2014-08-25       Impact factor: 29.690

Review 2.  A role for DNA methylation in vertebrate gene expression?

Authors:  J S Strobl
Journal:  Mol Endocrinol       Date:  1990-02

3.  Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.

Authors:  Andrei Kuzmichev; Kenichi Nishioka; Hediye Erdjument-Bromage; Paul Tempst; Danny Reinberg
Journal:  Genes Dev       Date:  2002-11-15       Impact factor: 11.361

Review 4.  The Landscape of long noncoding RNA classification.

Authors:  Georges St Laurent; Claes Wahlestedt; Philipp Kapranov
Journal:  Trends Genet       Date:  2015-04-10       Impact factor: 11.639

Review 5.  Mitochondrial dynamics in pulmonary arterial hypertension.

Authors:  John Ryan; Asish Dasgupta; Jessica Huston; Kuang-Huieh Chen; Stephen L Archer
Journal:  J Mol Med (Berl)       Date:  2015-02-13       Impact factor: 4.599

6.  Methylation Analysis of the BMPR2 Gene Promoter Region in Patients With Pulmonary Arterial Hypertension.

Authors:  Guillermo Pousada; Adolfo Baloira; Diana Valverde
Journal:  Arch Bronconeumol       Date:  2015-12-03       Impact factor: 4.872

7.  Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis.

Authors:  Ivan V Gregoretti; Yun-Mi Lee; Holly V Goodson
Journal:  J Mol Biol       Date:  2004-04-16       Impact factor: 5.469

8.  Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function.

Authors:  Matthias S Leisegang; Christian Fork; Ivana Josipovic; Florian Martin Richter; Jens Preussner; Jiong Hu; Matthew J Miller; Jeremy Epah; Patrick Hofmann; Stefan Günther; Franziska Moll; Chanil Valasarajan; Juliana Heidler; Yuliya Ponomareva; Thomas M Freiman; Lars Maegdefessel; Karl H Plate; Michel Mittelbronn; Shizuka Uchida; Carsten Künne; Konstantinos Stellos; Ralph T Schermuly; Norbert Weissmann; Kavi Devraj; Ilka Wittig; Reinier A Boon; Stefanie Dimmeler; Soni Savai Pullamsetti; Mario Looso; Francis J Miller; Ralf P Brandes
Journal:  Circulation       Date:  2017-03-28       Impact factor: 29.690

9.  Predicting nucleosome positions on the DNA: combining intrinsic sequence preferences and remodeler activities.

Authors:  Vladimir B Teif; Karsten Rippe
Journal:  Nucleic Acids Res       Date:  2009-07-22       Impact factor: 16.971

10.  Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.

Authors:  Lan Zhao; Chien-Nien Chen; Nabil Hajji; Eduardo Oliver; Emanuele Cotroneo; John Wharton; Daren Wang; Min Li; Timothy A McKinsey; Kurt R Stenmark; Martin R Wilkins
Journal:  Circulation       Date:  2012-06-18       Impact factor: 29.690
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  6 in total

Review 1.  Resveratrol as a potential therapeutic drug for respiratory system diseases.

Authors:  Xiao-Dan Zhu; Xiao-Ping Lei; Wen-Bin Dong
Journal:  Drug Des Devel Ther       Date:  2017-12-15       Impact factor: 4.162

2.  Different forms of pulmonary hypertension in a family with clinical and genetic evidence for hereditary hemorrhagic teleangectasia type 2.

Authors:  Alessandra Greco; Sara Plumitallo; Laura Scelsi; Giannantonio Maggi; Matteo Sobrero; Annalisa Turco; Claudia Raineri; Natalia Arseni; Donata Cappelletti; Luigi Oltrona Visconti; Fabio Pagella; Giuseppe Spinozzi; Stefano Ghio; Carla Olivieri; Cesare Danesino
Journal:  Pulm Circ       Date:  2018-05-25       Impact factor: 3.017

3.  miR-190a-5p participates in the regulation of hypoxia-induced pulmonary hypertension by targeting KLF15 and can serve as a biomarker of diagnosis and prognosis in chronic obstructive pulmonary disease complicated with pulmonary hypertension.

Authors:  Jing Jiang; Yimeng Xia; Yi Liang; Meiling Yang; Wen Zeng; Xiaocong Zeng
Journal:  Int J Chron Obstruct Pulmon Dis       Date:  2018-11-20

4.  BMPR2 promoter methylation and its expression in valvular heart disease complicated with pulmonary artery hypertension.

Authors:  Ni Li; Linwen Zhu; Caimin Zhu; Hua Zhou; Dawei Zheng; Guodong Xu; Huoshun Shi; Jianqing Gao; Albert Jiarui Li; Zhaoyang Wang; Lebo Sun; Xiajun Li; Guofeng Shao
Journal:  Aging (Albany NY)       Date:  2021-11-18       Impact factor: 5.682

5.  Weighted Gene Coexpression Network Analysis Identifies Crucial Genes Involved in Coronary Atherosclerotic Heart Disease.

Authors:  Jinli Bao
Journal:  Dis Markers       Date:  2022-08-02       Impact factor: 3.464

6.  LncRNA CASC2 inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation and migration by regulating the miR-222/ING5 axis.

Authors:  Yan Han; Yuhao Liu; Chaokuan Yang; Chuanyu Gao; Xiaoyan Guo; Jiangtao Cheng
Journal:  Cell Mol Biol Lett       Date:  2020-03-17       Impact factor: 5.787
  6 in total

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