| Literature DB >> 28572978 |
Sotirios P Fortis1, Michael Sofopoulos2, Sonia A Perez1, Constantin N Baxevanis1, Nectaria N Sotiriadou2, Christoforos Haritos1, Christoforos K Vaxevanis1, Eleftheria A Anastasopoulou1, Nicole Janssen3, Niki Arnogiannaki2, Alexandros Ardavanis4, Graham Pawelec3.
Abstract
[This corrects the article DOI: 10.1186/s40425-017-0240-7.].Entities:
Year: 2017 PMID: 28572978 PMCID: PMC5450300 DOI: 10.1186/s40425-017-0248-z
Source DB: PubMed Journal: J Immunother Cancer ISSN: 2051-1426 Impact factor: 13.751
Multivariate Cox proportional hazard analysis for DFS and OS of patients with non-mesastatic invasive breast cancer
| DFS | OS | |||||
|---|---|---|---|---|---|---|
| Hazard Ratio |
| 95.0% CI for HR (range) | Hazard Ratio |
| 95.0% CI for HR (range) | |
| TNM stageb | 2.180 | 0.009 | 1.219–3.898 | 3.937 | 0.006 | 1.494–10.371 |
| Signaturesb | 1.560 | 0.138 | 0.866–2.810 | 2.085 | 0.091 | 0.889–4.890 |
| Model before stepwise selection | ||||||
| Agea | 1.031 | 0.948 | 0.411–2.589 | 4.391 | 0.188 | 0.486–39.703 |
| T statusb | 2.613 | 0.010 | 1.255–5.439 | 3.679 | 0.028 | 1.148–11.793 |
| N stageb | 1.222 | 0.512 | 0.671–2.225 | 1.125 | 0.815 | 0.420–3.010 |
| Gradeb | 1.142 | 0.750 | 0.504–2.585 | 4.189 | 0.027 | 1.180–14.867 |
| HER-2/neu | 0.928 | 0.884 | 0.342–2.520 | 0.066 | 0.016 | 0.007–0.066 |
| Hormone Receptors | 0.277 | 0.004 | 0.277–0.669 | 0.618 | 0.007 | 0.046–0.621 |
| Signaturesb | 2.063 | 0.041 | 1.031–4.126 | 4.850 | 0.014 | 1.374–17.122 |
| Model after stepwise selection | ||||||
| T statusb | 2.999 | 0.001 | 1.602–5.615 | 3.522 | 0.005 | 1.477–8.398 |
| Hormone Receptors | 0.269 | 0.002 | 0.116–0.621 | 0.231 | 0.014 | 0.072–0.742 |
| Signaturesb | 2.146 | 0.027 | 1.091–4.219 | 4.273 | 0.006 | 1.521–11.999 |
aAge under 50 and over 50 years old
bAll categorical covariates were transformed into numeric codes as follows: T status (T1; 1, T2; 2, T3; 3), N stage (NO; 0, N1; 1, N2; 2, N3; 3), Grade (G1; 1, G2; 2, G3; 3), Signatures (FCIS; 1, Rest; 2, UCIS; 3) TNM stage (I; 1, II; 2, III; 3)