Literature DB >> 28572488

Detection of Synchronous Primary Malignancies with 68Ga-Labeled Prostate-Specific Membrane Antigen PET/CT in Patients with Prostate Cancer: Frequency in 764 Patients.

Medhat M Osman1, Amir Iravani2, Rodney J Hicks2,3, Michael S Hofman2,3.   

Abstract

We evaluated the incidence of synchronous primary malignancies in patients undergoing 68Ga-labeled prostate-specific membrane antigen PET/CT for prostate cancer (PC).
Methods: Reports for 764 PC patients were reviewed. Incidental lesions atypical for PC metastases and suggestive of a synchronous primary malignancy were identified. Follow-up was obtained to confirm etiology.
Results: Lesions atypical for PC metastases were found in 49 (6.4%) of 764 patients, and a synchronous primary malignancy was confirmed in 5 patients (0.7%; 2 lung, 1 lymphoma, 1 thyroid, and 1 base of tongue). In 8 patients (1.0%), lesions were proven to be atypical metastases from PC. In 24 patients (3.1%), lesions had a benign etiology. Follow-up was not available in 12 patients (1.6%).
Conclusion: Synchronous 68Ga-labeled prostate-specific membrane antigen-avid malignancies were rare (0.7%) in PC patients; atypical lesions were more commonly unusual PC metastases (1.0%) or benign (3.1%).
© 2017 by the Society of Nuclear Medicine and Molecular Imaging.

Entities:  

Keywords:  68Ga-PSMA; PET/CT; prostate cancer; synchronous primary malignancy

Mesh:

Substances:

Year:  2017        PMID: 28572488     DOI: 10.2967/jnumed.117.190215

Source DB:  PubMed          Journal:  J Nucl Med        ISSN: 0161-5505            Impact factor:   10.057


  12 in total

Review 1.  Targeting PSMA by radioligands in non-prostate disease-current status and future perspectives.

Authors:  Philipp Backhaus; Benjamin Noto; Nemanja Avramovic; Lena Sophie Grubert; Sebastian Huss; Martin Bögemann; Lars Stegger; Matthias Weckesser; Michael Schäfers; Kambiz Rahbar
Journal:  Eur J Nucl Med Mol Imaging       Date:  2018-01-15       Impact factor: 9.236

Review 2.  [The role of PSMA PET-CT in patients with metastatic prostate cancer].

Authors:  J von Hardenberg; K-A Büsing; P Nuhn; M Ritter
Journal:  Urologe A       Date:  2017-11       Impact factor: 0.639

Review 3.  [The role of PSMA PET-CT in patients with metastatic prostate cancer].

Authors:  J von Hardenberg; K-A Büsing; P Nuhn; M Ritter
Journal:  Radiologe       Date:  2018-03       Impact factor: 0.635

4.  PSMA expression level predicts differentiated thyroid cancer aggressiveness and patient outcome.

Authors:  Martina Sollini; Luca di Tommaso; Margarita Kirienko; Chiara Piombo; Marco Erreni; Andrea Gerardo Lania; Paola Anna Erba; Lidija Antunovic; Arturo Chiti
Journal:  EJNMMI Res       Date:  2019-10-15       Impact factor: 3.138

5.  A Case of Metachronous Triple Carcinoma with Synchronous Double Primary Carcinoma on 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography.

Authors:  Sarthak Tripathy; Asit Ranjan Mirdha; Shamim Ahmed Shamim; Girish Kumar Parida; Kishan Subudhi
Journal:  Indian J Nucl Med       Date:  2020-03-12

Review 6.  Nonprostatic diseases on PSMA PET imaging: a spectrum of benign and malignant findings.

Authors:  Felipe de Galiza Barbosa; Marcelo Araujo Queiroz; Rafael Fernandes Nunes; Larissa Bastos Costa; Elaine Caroline Zaniboni; José Flavio Gomes Marin; Giovanni Guido Cerri; Carlos Alberto Buchpiguel
Journal:  Cancer Imaging       Date:  2020-03-14       Impact factor: 3.909

7.  Intra-patient comparison of physiologic 68Ga-PSMA-11 and 18F-DCFPyL PET/CT uptake in ganglia in prostate cancer patients: a pictorial essay.

Authors:  Medhat M Osman; Amir Iravani; Michael S Hofman; Rodney J Hicks
Journal:  Cancer Imaging       Date:  2021-04-16       Impact factor: 3.909

8.  Nephrotoxicity after radionuclide therapies.

Authors:  Ashwin Singh Parihar; Sejal Chopra; Vikas Prasad
Journal:  Transl Oncol       Date:  2021-11-27       Impact factor: 4.243

9.  Nonspecific Uptake of 68Ga-Prostate-Specific Membrane Antigen in Diseases other than Prostate Malignancy on Positron Emission Tomography/Computed Tomography Imaging: A Pictorial Assay and Review of Literature.

Authors:  Dharmender Malik; Apurva Sood; Bhagwant Rai Mittal; Harmandeep Singh; Rajender Kumar Basher; Jaya Shukla; Anish Bhattacharya; Shrawan Kumar Singh
Journal:  Indian J Nucl Med       Date:  2018 Oct-Dec

10.  Incidental detection of primary hepatocellular carcinoma on 18F-prostate-specific membrane antigen-1007 positron emission tomography/computed tomography imaging in a patient with prostate cancer: A case report.

Authors:  Hongguang Zhao; Yinghua Li; Sen Hou; Yuyin Dai; Chenghe Lin; Songbai Xu
Journal:  Medicine (Baltimore)       Date:  2020-10-09       Impact factor: 1.817

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