| Literature DB >> 2857214 |
M V Ragni, A H Urbach, S Kiernan, J Stambouli, B Cohen, B S Rabin, A Winkelstein, J C Gartner, B Z Zitelli, J J Malatack.
Abstract
Oral thrush developed during the second month of life in the 5-month-old son of a patient with haemophilia A. He did not feed well, and interstitial pneumonitis, lymphadenopathy, hepatosplenomegaly, and a cellular immune defect consistent with the acquired immunodeficiency syndrome (AIDS) followed. Both parents had signs of pre-AIDS during the year before their son's illness. Transmission presumably occurred in 3 steps: parenterally, via factor VIII concentrate in the haemophiliac; heterosexually, from the haemophiliac to his wife; and vertically, from mother to infant, or via close paternal-infant or maternal-infant contact. This first report of AIDS in the child of a haemophiliac supports the theory that AIDS is caused by an infectious agent. Concentrate-treated haemophiliacs may transmit this agent to their spouses or children, resulting in pre-AIDS or AIDS.Entities:
Keywords: Acquired Immunodeficiency Syndrome; Age Factors; Americas; Biology; Blood Coagulation Effects; Case Studies; Child; Demographic Factors; Developed Countries; Developing Countries; Diseases; Family And Household; Family Characteristics; Family Relationships; Fathers; Hematological Effects; Hemic System; Hereditary Diseases; Hiv Infections; Infant; Mothers; North America; Northern America; Parents; Physiology; Population; Population Characteristics; United States; Viral Diseases; Youth
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Year: 1985 PMID： 2857214 DOI： 10.1016/s0140-6736(85)91904-x
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321