N Reyns1, H-A Leroy2, C Delmaire3, B Derre4, E Le-Rhun5, J-P Lejeune6. 1. Inserm U1189, Onco-Thai - Image Assisted Laser Therapy for Oncology, University of Lille, 59000 Lille, France; Department of Neurosurgery, CHU de Lille, 59000 Lille, France. Electronic address: nicolas.reyns@chru-lille.fr. 2. Department of Neurosurgery, CHU de Lille, 59000 Lille, France. 3. Department of Radiology, CHU de Lille, 59000 Lille, France. 4. Department of Neurosurgery, CHU de Lille, 59000 Lille, France; Department of Radiology, CHU de Lille, 59000 Lille, France. 5. Department of Neuro-oncology, CHU de Lille, 59000 Lille, France. 6. Inserm U1189, Onco-Thai - Image Assisted Laser Therapy for Oncology, University of Lille, 59000 Lille, France; Department of Neurosurgery, CHU de Lille, 59000 Lille, France.
Abstract
BACKGROUND: The aim of our study was to report the usefulness of intraoperative MRI guidance in the resection of brain lesions adjacent to eloquent areas. PATIENTS AND METHODS: A single center prospective series of gliomas amenable to optimized resection with intraoperative MRI between September 2014 and December 2015. RESULTS: The study included 56 patients. The median duration of the first intraoperative MRI was 38min, interquartile range (IQR 30-46). Fourteen patients (40%) underwent a second intraoperative MRI, which had a median duration of 26min (IQR, 18-30). The median total operative time was 265min (IQR, 242-337). After the first intraoperative MRI, the median residual glioma volume of the 35 gliomas adjacent to eloquent areas was 7.04cm3 (IQR, 2.22-13.8), which did not significantly differ from the other gliomas (P=0.07). After the second intraoperative MRI, the median residual glioma volume was 3.86cm3 (IQR, 0.82-6.99), which did not significantly differ from the other patients (P=0.700). On the postoperative MRI, the median extent of the glioma resections adjacent to eloquent areas was 99.78% (IQR, 88.9-100), which was not significantly different from the rest of the population (P=0.290). At 6 months after surgery, the median Karnofsky Performance Score was 90, and 2.8% of the patients presented a permanent new neurological deficit. CONCLUSION: Our results suggest that intraoperative MRI is an effective and safe technique to improve the extent of brain lesion resections close to eloquent areas.
BACKGROUND: The aim of our study was to report the usefulness of intraoperative MRI guidance in the resection of brain lesions adjacent to eloquent areas. PATIENTS AND METHODS: A single center prospective series of gliomas amenable to optimized resection with intraoperative MRI between September 2014 and December 2015. RESULTS: The study included 56 patients. The median duration of the first intraoperative MRI was 38min, interquartile range (IQR 30-46). Fourteen patients (40%) underwent a second intraoperative MRI, which had a median duration of 26min (IQR, 18-30). The median total operative time was 265min (IQR, 242-337). After the first intraoperative MRI, the median residual glioma volume of the 35 gliomas adjacent to eloquent areas was 7.04cm3 (IQR, 2.22-13.8), which did not significantly differ from the other gliomas (P=0.07). After the second intraoperative MRI, the median residual glioma volume was 3.86cm3 (IQR, 0.82-6.99), which did not significantly differ from the other patients (P=0.700). On the postoperative MRI, the median extent of the glioma resections adjacent to eloquent areas was 99.78% (IQR, 88.9-100), which was not significantly different from the rest of the population (P=0.290). At 6 months after surgery, the median Karnofsky Performance Score was 90, and 2.8% of the patients presented a permanent new neurological deficit. CONCLUSION: Our results suggest that intraoperative MRI is an effective and safe technique to improve the extent of brain lesion resections close to eloquent areas.
Authors: Joshua D Bernstock; Sam E Gary; Neil Klinger; Pablo A Valdes; Walid Ibn Essayed; Hannah E Olsen; Gustavo Chagoya; Galal Elsayed; Daisuke Yamashita; Patrick Schuss; Florian A Gessler; Pier Paolo Peruzzi; Asim K Bag; Gregory K Friedman Journal: Neurooncol Adv Date: 2022-05-26
Authors: Constantin Tuleasca; Henri-Arthur Leroy; Iulia Peciu-Florianu; Ondine Strachowski; Benoit Derre; Marc Levivier; Michael Schulder; Nicolas Reyns Journal: Neurosurg Rev Date: 2021-02-03 Impact factor: 3.042