Literature DB >> 28571676

Long non-coding RNA PCAT-1 over-expression promotes proliferation and metastasis in gastric cancer cells through regulating CDKN1A.

Mingjun Bi1, Hongmei Yu2, Bin Huang1, Cuiyan Tang3.   

Abstract

Prostate cancer-associated transcript1 (PCAT-1) is a novel lncRNA that involved in cell apoptosis and proliferation of prostate cancer. However, the role of PCAT-1 on gastric cancer remains unclear. In the present study, we found that PCAT-1 was increased in gastric cancer tissues and cell lines. Over-expression of PCAT-1 was correlated with poor overall survival in gastric cancer patients. PCAT-1 knockdown through shRNA in AGS and MGC-803 cells inhibited cell proliferation, migration and invasion by regulating CDKN1A. Our data suggested that PCAT-1 could play an oncogenic role in gastric cancer progression. Silencing PCAT-1 is a potential novel therapeutic approach for gastric cancer.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  CDKN1A; Gastric cancer; PCAT-1; lncRNA

Mesh：

Substances：

Year:  2017        PMID： 28571676     DOI： 10.1016/j.gene.2017.05.049

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  24 in total

1.  The GAS5/miR-222 Axis Regulates Proliferation of Gastric Cancer Cells Through the PTEN/Akt/mTOR Pathway.

Authors:  Yanhua Li; Junjiao Gu; Hong Lu
Journal:  Dig Dis Sci       Date:  2017-11-02       Impact factor: 3.199

Review 2.  The Emerging Role of Long Non-Coding RNAs in Esophageal Cancer: Functions in Tumorigenesis and Clinical Implications.

Authors:  Yali Han; Guo Zhao; Xinhang Shi; Yushan Wang; Xin Wen; Lu Zhang; Xiangqian Guo
Journal:  Front Pharmacol       Date:  2022-05-13       Impact factor: 5.988

3.  Long non-coding RNA PCAT1 drives clear cell renal cell carcinoma by upregulating YAP via sponging miR-656 and miR-539.

Authors:  Rui Wang; Bin Zheng; Hongyan Liu; Xiuxian Wan
Journal:  Cell Cycle       Date:  2020-04-14       Impact factor: 4.534

4.  Long non-coding RNA GPR65-1 is up-regulated in gastric cancer and promotes tumor growth through the PTEN-AKT-slug signaling pathway.

Authors:  Yansen Li; Zhanlong Shen; Bo Wang; Chunxiang Ye; Zhiyong Lai; Hongpeng Jiang; Zhu Wang; Kewei Jiang; Yingjiang Ye; Shan Wang
Journal:  Cell Cycle       Date:  2018-04-02       Impact factor: 4.534

5.  The lncRNA PCAT1 is correlated with poor prognosis and promotes cell proliferation, invasion, migration and EMT in osteosarcoma.

Authors:  Xuedong Zhang; Yakui Zhang; Yong Mao; Xinlong Ma
Journal:  Onco Targets Ther       Date:  2018-01-31       Impact factor: 4.147

6.  Identification of a five-long non-coding RNA signature to improve the prognosis prediction for patients with hepatocellular carcinoma.

Authors:  Qiu-Jie Zhao; Jiao Zhang; Lin Xu; Fang-Feng Liu
Journal:  World J Gastroenterol       Date:  2018-08-14       Impact factor: 5.742

7.  LncRNA PCAT-1 in gastrointestinal cancers: A meta-analysis.

Authors:  Wanwei Liu; Jiwei Xu
Journal:  Medicine (Baltimore)       Date:  2018-11       Impact factor: 1.817

Review 8.  Long non-coding RNAs involved in metastasis of gastric cancer.

Authors:  Meng-Ting Lin; Hao-Jun Song; Xiao-Yun Ding
Journal:  World J Gastroenterol       Date:  2018-09-07       Impact factor: 5.742

Review 9.  Role of microRNA-129 in cancer and non-cancerous diseases (Review).

Authors:  Bingpeng Deng; Xuan Tang; Yong Wang
Journal:  Exp Ther Med       Date:  2021-06-30       Impact factor: 2.447

10.  LncRNA-PCAT1 targeting miR-145-5p promotes TLR4-associated osteogenic differentiation of adipose-derived stem cells.

Authors:  Lingjia Yu; Hao Qu; Yifeng Yu; Wenjing Li; Yu Zhao; Guixing Qiu
Journal:  J Cell Mol Med       Date:  2018-10-19       Impact factor: 5.310
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