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Literature DB >> 28571560

The Use of Biomarkers in Sepsis: A Systematic Review.

Konstantinos Giannakopoulos¹, Ursula Hoffmann², Uzair Ansari¹, Thomas Bertsch², Martin Borggrefe¹, Ibrahim Akin¹, Michael Behnes¹.

Abstract

BACKGROUND: Despite the extended laboratory and clinical study of sepsis, its diagnosis remains a clinical challenge. The initiation of sepsis activates many different biochemical and immunological pathways being expressed by alterations of various molecules in human tissues. The detection and measurement of the concentration of such molecules, known as biomarkers, may be a diagnostic tool of great significance for clinicians dealing with suspected sepsis. Additionally, biomarkers may predict patients ´ outcome and may play a role in monitoring response to therapy.
METHODS: Most relevant clinical and experimental biomarker studies on sepsis were retrieved and reviewed in this article.
RESULTS: Although many biomarkers were evaluated for the diagnosis and prognosis in sepsis, until now not one has been proven to be absolutely reliable in the clinical field. Currently C-reactive proteine (CPR) and procalcitonin (PCT) are used worldwide routinely, nevertheless their values may elevate in clinical settings without sepsis, while they often fail to provide reliable prediction of the patient outcome.
CONCLUSION: This review outlines most relevant circulating biomarkers in sepsis. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities: Disease Gene Species

Keywords: Biomarkers; C-Reactive Protein (CPR); procalcitonin (PCT); prognosis; sepsis; septic shock

Mesh：

Substances：

Year: 2017 PMID： 28571560 DOI： 10.2174/1389201018666170601080111

Source DB: PubMed Journal: Curr Pharm Biotechnol ISSN： 1389-2010 Impact factor: 2.837

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Cited

19 in total

1. Inducible Nitric Oxide Synthase in Circulating Microvesicles: Discovery, Evolution, and Evidence as a Novel Biomarker and the Probable Causative Agent for Sepsis.

Authors: Robert J Webber; Richard M Sweet; Douglas S Webber
Journal: J Appl Lab Med Date: 2019-01

Review 2. Role of complement C5a and histones in septic cardiomyopathy.

Authors: Fatemeh Fattahi; Lynn M Frydrych; Guowu Bian; Miriam Kalbitz; Todd J Herron; Elizabeth A Malan; Matthew J Delano; Peter A Ward
Journal: Mol Immunol Date: 2018-06-18 Impact factor: 4.407

Review 3. Indian National Association for the Study of Liver Consensus Statement on Acute Liver Failure (Part-2): Management of Acute Liver Failure.

Authors: Anil C Anand; Bhaskar Nandi; Subrat K Acharya; Anil Arora; Sethu Babu; Yogesh Batra; Yogesh K Chawla; Abhijit Chowdhury; Ashok Chaoudhuri; Eapen C Eapen; Harshad Devarbhavi; Radha K Dhiman; Siddhartha Datta Gupta; Ajay Duseja; Dinesh Jothimani; Dharmesh Kapoor; Premashish Kar; Mohamad S Khuroo; Ashish Kumar; Kaushal Madan; Bipadabhanjan Mallick; Rakhi Maiwall; Neelam Mohan; Aabha Nagral; Preetam Nath; Sarat C Panigrahi; Ankush Pawar; Cyriac A Philips; Dibyalochan Prahraj; Pankaj Puri; Amit Rastogi; Vivek A Saraswat; Sanjiv Saigal; Akash Shukla; Shivaram P Singh; Thomas Verghese; Manav Wadhawan
Journal: J Clin Exp Hepatol Date: 2020-04-22

4. Ability of serum procalcitonin to distinguish focus of infection and pathogen types in patients with bloodstream infection.

Authors: Yinzhi Leng; Caiyun Chen; Yongxiang Zhang; Can Luo; Bo Liu
Journal: Ann Transl Med Date: 2019-04

5. Stigma, biomarkers, and algorithmic bias: recommendations for precision behavioral health with artificial intelligence.

Authors: Colin G Walsh; Beenish Chaudhry; Prerna Dua; Kenneth W Goodman; Bonnie Kaplan; Ramakanth Kavuluru; Anthony Solomonides; Vignesh Subbian
Journal: JAMIA Open Date: 2020-01-22

10. CT Image Feature under Intelligent Algorithm in the Evaluation of Continuous Blood Purification in the Treatment and Nursing of Pulmonary Infection-Caused Severe Sepsis.

Authors: Liping Liu; Yanyan Liu; Aimin Xing; Siyu Chen; Mingli Gu
Journal: Comput Math Methods Med Date: 2021-11-28 Impact factor: 2.238

The Use of Biomarkers in Sepsis: A Systematic Review.

1. Inducible Nitric Oxide Synthase in Circulating Microvesicles: Discovery, Evolution, and Evidence as a Novel Biomarker and the Probable Causative Agent for Sepsis.

Review 2. Role of complement C5a and histones in septic cardiomyopathy.

Review 3. Indian National Association for the Study of Liver Consensus Statement on Acute Liver Failure (Part-2): Management of Acute Liver Failure.

4. Ability of serum procalcitonin to distinguish focus of infection and pathogen types in patients with bloodstream infection.

5. Stigma, biomarkers, and algorithmic bias: recommendations for precision behavioral health with artificial intelligence.

6. Ultrasensitive digital quantification of cytokines and bacteria predicts septic shock outcomes.

7. Two Gene Set Variation Index as Biomarker of Bacterial and Fungal Sepsis.

8. Prediction of Sepsis in COVID-19 Using Laboratory Indicators.

Review 9. The role of endothelial shear stress on haemodynamics, inflammation, coagulation and glycocalyx during sepsis.

10. CT Image Feature under Intelligent Algorithm in the Evaluation of Continuous Blood Purification in the Treatment and Nursing of Pulmonary Infection-Caused Severe Sepsis.