Elena Inzaghi1, Barbara Baldini Ferroli1, Danilo Fintini1, Armando Grossi1, Valerio Nobili2, Stefano Cianfarani1,3. 1. Dipartimento Pediatrico Universitario Ospedaliero "Bambino Gesù" Children's Hospital-Tor Vergata University, Rome, Italy. 2. Hepato-Metabolic Department, "Bambino Gesù" Children's Hospital, Rome, Italy. 3. Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Abstract
BACKGROUND/AIMS: Insulin-like growth factor (IGF)-I is related to cardiometabolic risk in adults, whereas the metabolic role of IGF-II is unclear. The aim of this study was to assess IGFs in obese children and correlate them with metabolic syndrome (MetS) components. METHODS: This is a retrospective study including 574 obese children (11.34 ± 3.16 years). All subjects underwent complete anthropometry and biochemical assessment. In a subgroup of 136 subjects, body composition was evaluated. IGF-I was measured in 300 obese subjects and IGF-II in 77 obese and 15 lean children. 177 subjects were divided according to the presence of 1 or more MetS criteria: group 1, subjects with 1 MetS criterion; group 2, subjects with 2 components; and group 3, subjects with MetS diagnosis. RESULTS: IGF-I, IGF-II, and IGF-I/insulin-like growth factor-binding protein-3 ratio were not different among subjects with an increasing number of MetS criteria and were not associated with single components of MetS as well as with body composition parameters. In children younger than 10 years, IGF-I directly correlated with high-density lipoprotein cholesterol (p < 0.005) even after controlling for confounders. IGF-II was significantly higher in obese children and correlated with parameters of insulin sensitivity (p < 0.05). CONCLUSION: IGFs were neither related to MetS nor to body composition parameters in obese children. Further studies are needed to clarify the mechanisms underlying the relationship between IGF-II and insulin sensitivity.
BACKGROUND/AIMS: Insulin-like growth factor (IGF)-I is related to cardiometabolic risk in adults, whereas the metabolic role of IGF-II is unclear. The aim of this study was to assess IGFs in obesechildren and correlate them with metabolic syndrome (MetS) components. METHODS: This is a retrospective study including 574 obesechildren (11.34 ± 3.16 years). All subjects underwent complete anthropometry and biochemical assessment. In a subgroup of 136 subjects, body composition was evaluated. IGF-I was measured in 300 obese subjects and IGF-II in 77 obese and 15 lean children. 177 subjects were divided according to the presence of 1 or more MetS criteria: group 1, subjects with 1 MetS criterion; group 2, subjects with 2 components; and group 3, subjects with MetS diagnosis. RESULTS:IGF-I, IGF-II, and IGF-I/insulin-like growth factor-binding protein-3 ratio were not different among subjects with an increasing number of MetS criteria and were not associated with single components of MetS as well as with body composition parameters. In children younger than 10 years, IGF-I directly correlated with high-density lipoprotein cholesterol (p < 0.005) even after controlling for confounders. IGF-II was significantly higher in obesechildren and correlated with parameters of insulin sensitivity (p < 0.05). CONCLUSION: IGFs were neither related to MetS nor to body composition parameters in obesechildren. Further studies are needed to clarify the mechanisms underlying the relationship between IGF-II and insulin sensitivity.
Authors: A Blasetti; S Franchini; V Castorani; L Comegna; E Fornari; F Daniele; G Prezioso; C Piona; V Federico; D Zona; I Bresadola; F Chiarelli; C Maffeis Journal: Int J Endocrinol Date: 2020-10-10 Impact factor: 3.257
Authors: Daniel Åberg; N David Åberg; Katarina Jood; Petra Redfors; Christian Blomstrand; Jörgen Isgaard; Christina Jern; Johan Svensson Journal: Life (Basel) Date: 2021-05-29
Authors: Elena Inzaghi; Anna Kistner; Daniela Germani; Annalisa Deodati; Mireille Vanpee; Lena Legnevall; Katarina Berinder; Stefano Cianfarani Journal: PLoS One Date: 2020-01-24 Impact factor: 3.240