| Literature DB >> 2857074 |
M Osman, R R Kaldany, J O Cantor, G M Turino, I Mandl.
Abstract
Lysyl oxidase activity was measured in lung extracts of hamsters with elastase-induced emphysema 8 days after administration of the enzyme and again after 2, 3, and 4 wk. Levels of activity rose rapidly to 7 times the base values determined in the lungs of saline-injected control animals. In parallel with the increase in lysyl oxidase activity, the rate of 14C-lysine incorporation into desmosine and isodesmosine was at its maximum 1 wk after elastase administration, reflecting the lysyl-oxidase-mediated cross-link formation, which is the final step in the resynthesis of the pulmonary elastin destroyed by the elastolytic insult.Entities:
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Year: 1985 PMID： 2857074 DOI： 10.1164/arrd.1985.131.1.169
Source DB: PubMed Journal: Am Rev Respir Dis ISSN： 0003-0805