Literature DB >> 28567199

Frequent malaria illness episodes in two Malawian patients on antiretroviral therapy soon after stopping cotrimoxazole preventive therapy.

Wongani Js Nyangulu1, Edson Mwinjiwa1, Titus H Divala2, Randy G Mungwira2, Osward Nyirenda2, Maxwell Kanjala2, Gillian Mbambo3, Jane Mallewa4, Terrie E Taylor2, Matthew B Laurens3, Miriam K Laufer3, Joep J van Oosterhout1,4.   

Abstract

We describe two Malawian adults on successful antiretroviral therapy who experienced frequent malaria episodes after stopping cotrimoxazole prophylaxis. We argue that, in addition to stopping cotrimoxazole, diminished malaria immunity and drug interactions between efavirenz and artemether-lumefantrine may have played a causative role in the recurrent malaria our patients experienced.

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Year:  2017        PMID： 28567199      PMCID： PMC5442494          DOI： 10.4314/mmj.v29i1.12

Source DB:  PubMed          Journal:  Malawi Med J        ISSN： 1995-7262            Impact factor:   0.875


  19 in total

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