The global HIV epidemic: What the pathologist needs to know.

The World Health Organization estimates that at the end of 2015, approximately 36.7 million people were living with HIV worldwide. An estimated 0.8% of adults aged 15-49 years are infected with HIV with women representing a little over half of these infections. The burden of the epidemic varies considerably between regions of the world and within countries. Sub-Saharan Africa is the region of the world with most infections accounting for approximately 70% of people living with HIV. In the United States the number of new infections decreased by 19% between 2005 and 2014 yet, close to 40,000 new infections occurred in 2015 and, as people with HIV live longer and new infections continue, the number of people living with HIV in the US now stands at nearly 1.2 million and continues to rise. Unprecedented funding initiatives for antiretroviral therapy have resulted in coverage of up to 46% of those in need globally. In recent years, studies have demonstrated that HIV-infected persons who are on antiretroviral therapy and suppressed do not transmit HIV thus the United Nations AIDS Program (UNAIDS) initiative of "treatment is prevention". The UNAIDS goals for 2020 are to have diagnosis of 90% of those infected, 90% of those infected will be on treatment and in 90% there will be viral suppression. Of note, for two of the goals, laboratory system strengthening is paramount.