OBJECTIVE: Although alterations in the dendritic spine density in the brain regions may play a role in the stress-induced depression-like phenotype, the precise mechanisms are unknown. The aim was to investigate the role of spine density in the brain regions after chronic social defeat stress (CSDS). METHODS: We examined dendritic spine density in the medial prefrontal cortex (mPFC), CA1, CA3, dentate gyrus (DG) of hippocampus, nucleus accumbens (NAc), and ventral tegmental area (VTA) of susceptible and resilient mice after CSDS. RESULTS: Spine density in the prelimbic area of mPFC, CA3, and DG in the susceptible group, but not resilient group, was significantly lower than control group. In contrast, spine density in the NAc and VTA in the susceptible group, but not resilient group, was significantly higher than control group. CONCLUSIONS: The results suggest that regional differences in spine density may contribute to resilience versus susceptibility in mice subjected to CSDS.
OBJECTIVE: Although alterations in the dendritic spine density in the brain regions may play a role in the stress-induced depression-like phenotype, the precise mechanisms are unknown. The aim was to investigate the role of spine density in the brain regions after chronic social defeat stress (CSDS). METHODS: We examined dendritic spine density in the medial prefrontal cortex (mPFC), CA1, CA3, dentate gyrus (DG) of hippocampus, nucleus accumbens (NAc), and ventral tegmental area (VTA) of susceptible and resilient mice after CSDS. RESULTS: Spine density in the prelimbic area of mPFC, CA3, and DG in the susceptible group, but not resilient group, was significantly lower than control group. In contrast, spine density in the NAc and VTA in the susceptible group, but not resilient group, was significantly higher than control group. CONCLUSIONS: The results suggest that regional differences in spine density may contribute to resilience versus susceptibility in mice subjected to CSDS.
Authors: Maura Boldrini; Hanga Galfalvy; Andrew J Dwork; Gorazd B Rosoklija; Iskra Trencevska-Ivanovska; Goran Pavlovski; René Hen; Victoria Arango; J John Mann Journal: Biol Psychiatry Date: 2019-01-17 Impact factor: 13.382
Authors: Courtney K Walker; Kelsey M Greathouse; Evan Liu; Hamad M Muhammad; Benjamin D Boros; Cameron D Freeman; Jung Vin Seo; Jeremy H Herskowitz Journal: Neuroscience Date: 2022-06-23 Impact factor: 3.708