Literature DB >> 2856443

[Establishment and characterization of a human cholangiocellular carcinoma cell line].

Y Kusaka1, A Muraoka, T Tokiwa, J Sato.   

Abstract

A cell line, HuH-28 was established in vitro from a patient with cholangiocellular carcinoma (CCC). This cell line has been in continuous culture over 10 month period with slow growth potential. HuH-28 was composed of spindle-shaped cells as major population besides a small percentage of polygonal-shaped cells. Chromosome number of the cells were distributed near the hypotriploid region on the 3rd passage. HuH-28 cells were not transplantable into nude mice, but secreted some tumor markers including alkaline phosphatase (ALP), gamma glutamyltranspeptidase (GGT), beta 2-microglobulin (BMG), ferritin, elastase-1 and tissue polypeptide antigen (TPA). This HuH-28 cell line will represent a good model for the investigation of carcinogenesis, histogenesis+ and diagnosis of CCC.

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Year:  1988        PMID： 2856443

Source DB:  PubMed          Journal:  Hum Cell        ISSN： 0914-7470            Impact factor:   4.174


  9 in total

1.  Neuropeptide Y inhibits cholangiocarcinoma cell growth and invasion.

Authors:  Sharon DeMorrow; Paolo Onori; Julie Venter; Pietro Invernizzi; Gabriel Frampton; Mellanie White; Antonio Franchitto; Shelley Kopriva; Francesca Bernuzzi; Heather Francis; Monique Coufal; Shannon Glaser; Giammarco Fava; Fanyin Meng; Domenico Alvaro; Guido Carpino; Eugenio Gaudio; Gianfranco Alpini
Journal:  Am J Physiol Cell Physiol       Date:  2011-01-26       Impact factor: 4.249

2.  miR-34a-dependent overexpression of Per1 decreases cholangiocarcinoma growth.

Authors:  Yuyan Han; Fanyin Meng; Julie Venter; Nan Wu; Ying Wan; Holly Standeford; Heather Francis; Cynthia Meininger; John Greene; Jerome P Trzeciakowski; Laurent Ehrlich; Shannon Glaser; Gianfranco Alpini
Journal:  J Hepatol       Date:  2016-02-24       Impact factor: 25.083

3.  Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma.

Authors:  Heather Francis; Sharon DeMorrow; Julie Venter; Paolo Onori; Mellanie White; Eugenio Gaudio; Taylor Francis; John F Greene; Steve Tran; Cynthia J Meininger; Gianfranco Alpini
Journal:  Gut       Date:  2011-08-26       Impact factor: 23.059

4.  Simvastatin stimulates apoptosis in cholangiocarcinoma by inhibition of Rac1 activity.

Authors:  Timothy Miller; Fuquan Yang; Candace E Wise; Fanyin Meng; Sally Priester; Md Kamruzzaman Munshi; Micheleine Guerrier; David E Dostal; Shannon S Glaser
Journal:  Dig Liver Dis       Date:  2011-02-21       Impact factor: 4.088

5.  Melatonin exerts by an autocrine loop antiproliferative effects in cholangiocarcinoma: its synthesis is reduced favoring cholangiocarcinoma growth.

Authors:  Yuyan Han; Sharon Demorrow; Pietro Invernizzi; Qing Jing; Shannon Glaser; Anastasia Renzi; Fanyin Meng; Julie Venter; Francesca Bernuzzi; Mellanie White; Heather Francis; Ana Lleo; Marco Marzioni; Paolo Onori; Domenico Alvaro; Guido Torzilli; Eugenio Gaudio; Gianfranco Alpini
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2011-07-21       Impact factor: 4.052

6.  Leptin enhances cholangiocarcinoma cell growth.

Authors:  Giammarco Fava; Gianfranco Alpini; Chiara Rychlicki; Stefania Saccomanno; Sharon DeMorrow; Luciano Trozzi; Cinzia Candelaresi; Julie Venter; Antonio Di Sario; Marco Marzioni; Italo Bearzi; Shannon Glaser; Domenico Alvaro; Luca Marucci; Heather Francis; Gianluca Svegliati-Baroni; Antonio Benedetti
Journal:  Cancer Res       Date:  2008-08-15       Impact factor: 12.701

7.  H3 histamine receptor-mediated activation of protein kinase Calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo.

Authors:  Heather Francis; Paolo Onori; Eugenio Gaudio; Antonio Franchitto; Sharon DeMorrow; Julie Venter; Shelley Kopriva; Guido Carpino; Romina Mancinelli; Mellanie White; Fanyin Meng; Antonella Vetuschi; Roberta Sferra; Gianfranco Alpini
Journal:  Mol Cancer Res       Date:  2009-10-13       Impact factor: 5.852

8.  Human cholangiocarcinoma development is associated with dysregulation of opioidergic modulation of cholangiocyte growth.

Authors:  M Marzioni; P Invernizzi; C Candelaresi; M Maggioni; S Saccomanno; C Selmi; C Rychlicki; L Agostinelli; B Cassani; M Miozzo; S Pasini; G Fava; G Alpini; A Benedetti
Journal:  Dig Liver Dis       Date:  2008-10-22       Impact factor: 4.088

9.  Serotonin metabolism is dysregulated in cholangiocarcinoma, which has implications for tumor growth.

Authors:  Gianfranco Alpini; Pietro Invernizzi; Eugenio Gaudio; Julie Venter; Shelley Kopriva; Francesca Bernuzzi; Paolo Onori; Antonio Franchitto; Monique Coufal; Gabriel Frampton; Domenico Alvaro; Sum P Lee; Marco Marzioni; Antonio Benedetti; Sharon DeMorrow
Journal:  Cancer Res       Date:  2008-11-15       Impact factor: 12.701
  9 in total

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