Literature DB >> 28562165

HER-2/Epstein-Barr virus crosstalk in human gastric carcinogenesis: A novel concept of oncogene/oncovirus interaction.

Farhan S Cyprian1, Noor Al-Antary1, Ala-Eddin Al Moustafa1,2,3,4.   

Abstract

Gastric cancer is the fourth most common cancer and the second leading cause of cancer deaths worldwide. Additionally, it is well-known that metastatic cancer disease is a major cause of morbidity and mortality in cancer patients. Several investigations reported that HER-2 (ErbB-2 receptor) and Epstein-Barr virus (EBV) are important etiological factors in human gastric cancer, where either oncogene/oncovirus alone can derive a major event of cancer progression and metastasis via epithelial-mesenchymal transition (EMT). Herein, we discuss, for the first time, the possibility of HER-2/EBV-oncoproteins interaction in human gastric cancer initiation and/or progression.

Entities:  

Keywords:  EBV; HER-2; cancer initiation and progression; gastric cancer; oncogene/oncovirus cooperation

Mesh：

Substances：

Year:  2017        PMID： 28562165      PMCID： PMC5810752          DOI： 10.1080/19336918.2017.1330244

Source DB:  PubMed          Journal:  Cell Adh Migr        ISSN： 1933-6918            Impact factor:   3.405


  19 in total

1.  EBV-miR-BART7-3p promotes the EMT and metastasis of nasopharyngeal carcinoma cells by suppressing the tumor suppressor PTEN.

Authors:  L-M Cai; X-M Lyu; W-R Luo; X-F Cui; Y-F Ye; C-C Yuan; Q-X Peng; D-H Wu; T-F Liu; E Wang; F-M Marincola; K-T Yao; W-Y Fang; H-B Cai; X Li
Journal:  Oncogene       Date:  2014-10-27       Impact factor: 9.867

Review 2.  Extracellular region of epidermal growth factor receptor: a potential target for anti-EGFR drug discovery.

Authors:  A Dokala; S S Thakur
Journal:  Oncogene       Date:  2016-10-24       Impact factor: 9.867

Review 3.  Epstein-Barr virus: 40 years on.

Authors:  Lawrence S Young; Alan B Rickinson
Journal:  Nat Rev Cancer       Date:  2004-10       Impact factor: 60.716

Review 4.  High-risk HPV/ErbB-2 interaction on E-cadherin/catenin regulation in human carcinogenesis.

Authors:  Ala-Eddin Al Moustafa; Amal Kassab; Andrew Darnel; Amber Yasmeen
Journal:  Curr Pharm Des       Date:  2008       Impact factor: 3.116

5.  Cyclin D1 is essential for neoplastic transformation induced by both E6/E7 and E6/E7/ErbB-2 cooperation in normal cells.

Authors:  Ala-Eddin Al Moustafa; William D Foulkes; Annick Wong; Houda Jallal; Gerald Batist; Qunyan Yu; Meenhard Herlyn; Piotr Sicinski; Moulay A Alaoui-Jamali
Journal:  Oncogene       Date:  2004-07-01       Impact factor: 9.867

Review 6.  Epstein-Barr virus and cancer.

Authors:  Matthew P Thompson; Razelle Kurzrock
Journal:  Clin Cancer Res       Date:  2004-02-01       Impact factor: 12.531

Review 7.  EGF-receptor signaling and epithelial-mesenchymal transition in human carcinomas.

Authors:  Ala-Eddin Al Moustafa; Amal Achkhar; Amber Yasmeen
Journal:  Front Biosci (Schol Ed)       Date:  2012-01-01

Review 8.  Epstein-barr virus vaccines.

Authors:  Jeffrey I Cohen
Journal:  Clin Transl Immunology       Date:  2015-01-23

9.  Epstein-Barr virus latent membrane protein 2A suppresses the expression of HER2 via a pathway involving TWIST and YB-1 in Epstein-Barr virus-associated gastric carcinomas.

Authors:  Yi-wang Zhang; Xiao-xiao Zhao; Cui Tan; Zhi-gang Zhang; Ye Jiang; Jian-ning Chen; Hong-bo Wei; Ling Xue; Hai-gang Li; Hong Du; Chun-kui Shao
Journal:  Oncotarget       Date:  2015-01-01

10.  Epstein-barr virus infected gastric adenocarcinoma expresses latent and lytic viral transcripts and has a distinct human gene expression profile.

Authors:  Weihua Tang; Douglas R Morgan; Michael O Meyers; Ricardo L Dominguez; Enrique Martinez; Kennichi Kakudo; Pei Fen Kuan; Natalie Banet; Hind Muallem; Kimberly Woodward; Olga Speck; Margaret L Gulley
Journal:  Infect Agent Cancer       Date:  2012-08-28       Impact factor: 2.965
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  3 in total

Review 1.  Epstein-Barr Virus and Human Papillomaviruses Interactions and Their Roles in the Initiation of Epithelial-Mesenchymal Transition and Cancer Progression.

Authors:  Farhan S Cyprian; Halema F Al-Farsi; Semir Vranic; Saghir Akhtar; Ala-Eddin Al Moustafa
Journal:  Front Oncol       Date:  2018-05-01       Impact factor: 6.244

Review 2.  Epstein-Barr Virus-Encoded Products Promote Circulating Tumor Cell Generation: A Novel Mechanism of Nasopharyngeal Carcinoma Metastasis.

Authors:  Zongbei Yang; Jing Wang; Zhenlin Zhang; Faqing Tang
Journal:  Onco Targets Ther       Date:  2019-12-31       Impact factor: 4.147

3.  Bioinformatics Analysis of Potential Key Genes in Trastuzumab-Resistant Gastric Cancer.

Authors:  Guangda Yang; Liumeng Jian; Xiangan Lin; Aiyu Zhu; Guohua Wen
Journal:  Dis Markers       Date:  2019-12-17       Impact factor: 3.434
  3 in total

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