Takeshi Kera1,2, Hisashi Kawai3, Hirohiko Hirano3, Motonaga Kojima4, Yoshinori Fujiwara3, Kazushige Ihara5, Shuichi Obuchi3. 1. Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan. kera@tmig.or.jp. 2. Japanese Red Cross Ogawa Hospital, Saitama, Japan. kera@tmig.or.jp. 3. Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan. 4. University of Tokyo Health Sciences, Tokyo, Japan. 5. Toho University School of Medicine, Tokyo, Japan.
Abstract
BACKGROUND AND AIM: Although respiratory muscle strength is known to decrease with age, the relationship between pulmonary function and sarcopenia remains to be examined. The present study aimed to determine the relationship between peak expiratory flow rate (PEFR) and skeletal muscle mass/sarcopenia in community-dwelling older adults. METHODS: We utilized data from 427 older adults (age 74.4 ± 5.3 years, men/women 157/270) who had participated in the 2015 Otassha Kenshin, a longitudinal study that excluded participants with air-flow limitations. Diagnoses of sarcopenia were based on criteria outlined in the Consensus Report of the Asian Working Group for Sarcopenia and adjusted for Japanese individuals. We compared body composition, physical function, and lung function between patients with and without sarcopenia. Receiver operating characteristic analysis (ROC) for sarcopenia was performed using PEFR, calf circumference, and body mass index. RESULTS: Sixty-five participants (men/women 12/53) were diagnosed with sarcopenia. Patients with sarcopenia were older than those without sarcopenia, and had lower height, weight, body mass index, skeletal muscle mass, appendicular skeletal mass, and skeletal muscle index. Stepwise multiple regression analysis identified whole-body skeletal mass as an independent factor for PEFR. ROC analysis of sarcopenia identified a cut-off value of 5.0 L s for PEFR, with a sensitivity of 0.62, specificity of 0.77, and area under the curve of 0.73 (95% CI 0.67-0.79; P < 0.001). DISCUSSION AND CONCLUSION: Our findings suggest that physical function is more strongly associated with respiratory muscle mass than total skeletal muscle mass and that PEFR may be a valid indicator of sarcopenia.
BACKGROUND AND AIM: Although respiratory muscle strength is known to decrease with age, the relationship between pulmonary function and sarcopenia remains to be examined. The present study aimed to determine the relationship between peak expiratory flow rate (PEFR) and skeletal muscle mass/sarcopenia in community-dwelling older adults. METHODS: We utilized data from 427 older adults (age 74.4 ± 5.3 years, men/women 157/270) who had participated in the 2015 Otassha Kenshin, a longitudinal study that excluded participants with air-flow limitations. Diagnoses of sarcopenia were based on criteria outlined in the Consensus Report of the Asian Working Group for Sarcopenia and adjusted for Japanese individuals. We compared body composition, physical function, and lung function between patients with and without sarcopenia. Receiver operating characteristic analysis (ROC) for sarcopenia was performed using PEFR, calf circumference, and body mass index. RESULTS: Sixty-five participants (men/women 12/53) were diagnosed with sarcopenia. Patients with sarcopenia were older than those without sarcopenia, and had lower height, weight, body mass index, skeletal muscle mass, appendicular skeletal mass, and skeletal muscle index. Stepwise multiple regression analysis identified whole-body skeletal mass as an independent factor for PEFR. ROC analysis of sarcopenia identified a cut-off value of 5.0 L s for PEFR, with a sensitivity of 0.62, specificity of 0.77, and area under the curve of 0.73 (95% CI 0.67-0.79; P < 0.001). DISCUSSION AND CONCLUSION: Our findings suggest that physical function is more strongly associated with respiratory muscle mass than total skeletal muscle mass and that PEFR may be a valid indicator of sarcopenia.
Authors: D G Ohara; M S Pegorari; N L Oliveira Dos Santos; C de Fátima Ribeiro Silva; M S R Oliveira; A P Matos; M Jamami Journal: J Nutr Health Aging Date: 2020 Impact factor: 4.075
Authors: Francesco Landi; Sara Salini; Maria Beatrice Zazzara; Anna Maria Martone; Sofia Fabrizi; Mariangela Bianchi; Matteo Tosato; Anna Picca; Riccardo Calvani; Emanuele Marzetti Journal: J Cachexia Sarcopenia Muscle Date: 2019-12-04 Impact factor: 12.910