Literature DB >> 28559258

In Vitro Efficacy of Moxidectin versus Ivermectin against Sarcoptes scabiei.

Kate E Mounsey1, Shelley F Walton2, Ashlee Innes2, Skye Cash-Deans2, James S McCarthy3,4.   

Abstract

Moxidectin is under consideration for development as a treatment for human scabies. As some arthropods show decreased sensitivity to moxidectin relative to ivermectin, it was important to assess this for Sarcoptes scabieiIn vitro assays showed that the concentration of moxidectin required to kill 50% of mites was lower than that of ivermectin (0.5 μM versus 1.8 μM at 24 h; P < 0.0001). This finding provides further support for moxidectin as a candidate for the treatment of human scabies.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  Sarcoptes scabiei; ivermectin; moxidectin; scabies; treatment

Mesh：

Substances：

Year:  2017        PMID： 28559258      PMCID： PMC5527648          DOI： 10.1128/AAC.00381-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  35 in total

1.  Rapid and preferential sebum secretion of ivermectin: a new factor that may determine drug responsiveness in patients with scabies.

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Journal:  Arch Dermatol       Date:  2002-12

Review 2.  The pharmacokinetics and metabolism of ivermectin in domestic animal species.

Authors:  Aránzazu González Canga; Ana M Sahagún Prieto; M José Diez Liébana; Nélida Fernández Martínez; Matilde Sierra Vega; Juan J García Vieitez
Journal:  Vet J       Date:  2007-09-11       Impact factor: 2.688

3.  Comparative evaluation of systemic drugs for their effects against Anopheles gambiae.

Authors:  Matthew P Butters; Kevin C Kobylinski; Kelsey M Deus; Ines Marques da Silva; Meg Gray; Massamba Sylla; Brian D Foy
Journal:  Acta Trop       Date:  2011-10-14       Impact factor: 3.112

4.  Moxidectin in cattle: correlation between plasma and target tissues disposition.

Authors:  A Lifschitz; G Virkel; F Imperiale; J F Sutra; P Galtier; C Lanusse; M Alvinerie
Journal:  J Vet Pharmacol Ther       Date:  1999-08       Impact factor: 1.786

5.  A novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time monitoring of parasite motility.

Authors:  Michael J Smout; Andrew C Kotze; James S McCarthy; Alex Loukas
Journal:  PLoS Negl Trop Dis       Date:  2010-11-16

6.  Comparison of ivermectin and benzyl benzoate for treatment of scabies.

Authors:  P Glaziou; J L Cartel; P Alzieu; C Briot; J P Moulia-Pelat; P M Martin
Journal:  Trop Med Parasitol       Date:  1993-12

7.  Brugia malayi: in vitro effects of ivermectin and moxidectin on adults and microfilariae.

Authors:  J B Tompkins; L E Stitt; B F Ardelli
Journal:  Exp Parasitol       Date:  2009-12-23       Impact factor: 2.011

8.  A tractable experimental model for study of human and animal scabies.

Authors:  Kate Mounsey; Mei-Fong Ho; Andrew Kelly; Charlene Willis; Cielo Pasay; David J Kemp; James S McCarthy; Katja Fischer
Journal:  PLoS Negl Trop Dis       Date:  2010-07-20

9.  Prospects for Moxidectin as a New Oral Treatment for Human Scabies.

Authors:  Kate E Mounsey; Charlotte Bernigaud; Olivier Chosidow; James S McCarthy
Journal:  PLoS Negl Trop Dis       Date:  2016-03-17

10.  Preclinical Study of Single-Dose Moxidectin, a New Oral Treatment for Scabies: Efficacy, Safety, and Pharmacokinetics Compared to Two-Dose Ivermectin in a Porcine Model.

Authors:  Charlotte Bernigaud; Fang Fang; Katja Fischer; Anne Lespine; Ludwig Serge Aho; Dominique Dreau; Andrew Kelly; Jean-François Sutra; Francis Moreau; Thomas Lilin; Françoise Botterel; Jacques Guillot; Olivier Chosidow
Journal:  PLoS Negl Trop Dis       Date:  2016-10-12
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  6 in total

1.  In Vitro Activity of Beauvericin against All Developmental Stages of Sarcoptes scabiei.

Authors:  Charbel Al Khoury; Nabil Nemer; Georges Nemer; Mazen Kurban; Charlotte Bernigaud; Katja Fischer; Jacques Guillot
Journal:  Antimicrob Agents Chemother       Date:  2020-04-21       Impact factor: 5.191

2.  Effects of an injectable long-acting formulation of ivermectin on Onchocerca ochengi in zebu cattle.

Authors:  Michel Boussinesq; Peter Enyong; Patrick Chounna-Ndongmo; Abdel-Jelil Njouendou; Sébastien David Pion; Anthony Rech; Christophe Roberge; Georges Gaudriault; Samuel Wanji
Journal:  Parasite       Date:  2020-05-18       Impact factor: 3.000

3.  Drug dose and animal welfare: important considerations in the treatment of wildlife.

Authors:  Kate Mounsey; Robert J Harvey; Victoria Wilkinson; Kotaro Takano; Julie Old; Hayley Stannard; Leanne Wicker; David Phalen; Scott Carver
Journal:  Parasitol Res       Date:  2022-02-11       Impact factor: 2.383

4.  Ivermectin Plasma Concentration in Iberian Ibex (Capra pyrenaica) Following Oral Administration: A Pilot Study.

Authors:  Barbara Moroni; José Enrique Granados Torres; Jorge Ramón López-Olvera; José Espinosa Cerrato; Arián Ráez Bravo; Gregorio Mentaberre; Paulino Fandos; Marco Pazzi; Monica Romagnoli; Giulia Gardini; Luca Rossi; Marta Valldeperes; Emmanuel Serrano; Blanca Ramos; Rosangela Odore
Journal:  Front Vet Sci       Date:  2022-04-01

Review 5.  The Skin-A Common Pathway for Integrating Diagnosis and Management of NTDs.

Authors:  David John Chandler; Lucinda Claire Fuller
Journal:  Trop Med Infect Dis       Date:  2018-09-10

Review 6.  Integrated Management of Skin NTDs-Lessons Learned from Existing Practice and Field Research.

Authors:  Rie R Yotsu
Journal:  Trop Med Infect Dis       Date:  2018-11-14
  6 in total

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