Michail Matalliotakis1, George N Goulielmos2, Charoula Matalliotaki3, Alexandra Trivli4, Ioannis Matalliotakis5, Aydin Arici6. 1. Department of Obstetrics and Gynecology, Venizeleio and Pananio General Hospital of Heraklion, Crete, Greece; Section of Molecular Pathology and Human Genetics Department of Internal Medicine, School of Medicine University of Crete, Crete, Greece. Electronic address: mihalismat@hotmail.com. 2. Section of Molecular Pathology and Human Genetics Department of Internal Medicine, School of Medicine University of Crete, Crete, Greece. 3. Department of Surgery, General Hospital of Agios Nikolaos, Lasithi, Crete, Greece. 4. Department of Ophthalmology, Konstantopouleio General Hospital, Athens, Greece. 5. Department of Obstetrics and Gynecology, Venizeleio and Pananio General Hospital of Heraklion, Crete, Greece. 6. Department of Obstetrics and Gynecology and Reproductive Sciences Yale University School of Medicine, New Haven, Connecticut.
Abstract
STUDY OBJECTIVE: The aim of this retrospective study was to evaluate endometriosis in adolescent and young girls and further to review the menstrual, reproductive characteristics, and risk factors. DESIGN AND SETTING: We reviewed the medical records of adolescent and young girls with endometriosis from 2 different countries. Data were collected and analyzed from charts of 900 patients with endometriosis. PARTICIPANTS AND INTERVENTIONS: Fifty-five female adolescents aged between 13 and 21 years (mean age 18.3 years) participated in our series. This study was conducted in the Obstetric and Gynecology Department of Venizeleio General Hospital of Crete and involved all patients diagnosed with endometriosis between 1996 and 2016. MAIN OUTCOME MEASURES: Statistical methods included χ2 and Mann-Whitney U test. RESULTS: Of 900 patients with endometriosis we found 55 female adolescents (6.1%). The mean age was 18.3 ± 2.3 years, significantly younger compared with the advanced endometriosis patients (32.7 ± 7.2; P < .001). Regarding the menstrual reproductive and others characteristics, we observed several differences in adolescent young girls compared with the advanced age endometriosis group. The factors associated with an increased risk for young women include age at menarche, dysmenorrhea, history of asthma, and a positive family history of endometriosis. Additionally, we report on 16 of 55 (32%) adolescent women with endometriosis and congenital malformations (P < .01) and 5 patients who were diagnosed with dry eye syndrome. CONCLUSION: There is an association between endometriosis in adolescent and young women and risk factors including early menarche, early onset of dysmenorrhea, history of asthma, previous surgical procedures, obstructive genital anomalies, and family history of endometriosis.
STUDY OBJECTIVE: The aim of this retrospective study was to evaluate endometriosis in adolescent and young girls and further to review the menstrual, reproductive characteristics, and risk factors. DESIGN AND SETTING: We reviewed the medical records of adolescent and young girls with endometriosis from 2 different countries. Data were collected and analyzed from charts of 900 patients with endometriosis. PARTICIPANTS AND INTERVENTIONS: Fifty-five female adolescents aged between 13 and 21 years (mean age 18.3 years) participated in our series. This study was conducted in the Obstetric and Gynecology Department of Venizeleio General Hospital of Crete and involved all patients diagnosed with endometriosis between 1996 and 2016. MAIN OUTCOME MEASURES: Statistical methods included χ2 and Mann-Whitney U test. RESULTS: Of 900 patients with endometriosis we found 55 female adolescents (6.1%). The mean age was 18.3 ± 2.3 years, significantly younger compared with the advanced endometriosispatients (32.7 ± 7.2; P < .001). Regarding the menstrual reproductive and others characteristics, we observed several differences in adolescent young girls compared with the advanced age endometriosis group. The factors associated with an increased risk for young women include age at menarche, dysmenorrhea, history of asthma, and a positive family history of endometriosis. Additionally, we report on 16 of 55 (32%) adolescent women with endometriosis and congenital malformations (P < .01) and 5 patients who were diagnosed with dry eye syndrome. CONCLUSION: There is an association between endometriosis in adolescent and young women and risk factors including early menarche, early onset of dysmenorrhea, history of asthma, previous surgical procedures, obstructive genital anomalies, and family history of endometriosis.
Authors: Charoula Matalliotaki; Michail Matalliotakis; Maria I Zervou; Alexandra Trivli; Ioannis Matalliotakis; George Mavromatidis; Demetrios A Spandidos; Hans M Albertsen; Rakesh Chettier; Kenneth Ward; George N Goulielmos Journal: Mol Med Rep Date: 2018-10-01 Impact factor: 2.952
Authors: Krzysztof Gałczyński; Maciej Jóźwik; Dorota Lewkowicz; Anna Semczuk-Sikora; Andrzej Semczuk Journal: J Ovarian Res Date: 2019-11-07 Impact factor: 4.234
Authors: Kerstin Becker; Klaas Heinemann; Bruno Imthurn; Lena Marions; Sabine Moehner; Christoph Gerlinger; Marco Serrani; Thomas Faustmann Journal: Sci Rep Date: 2021-10-14 Impact factor: 4.379
Authors: Jhumka Gupta; Lauren F Cardoso; Courtney S Harris; Arielle D Dance; Tamer Seckin; Nina Baker; Yvonne O Ferguson Journal: BMJ Open Date: 2018-06-04 Impact factor: 2.692
Authors: Charoula Matalliotaki; Michail Matalliotakis; Maria I Zervou; Athina Patelarou; Ioannis Koliarakis; Demetrios A Spandidos; Aydin Arici; Ioannis Matalliotakis; George N Goulielmos Journal: Exp Ther Med Date: 2019-12-05 Impact factor: 2.447