| Literature DB >> 28558874 |
Wen-Zhao Tang1, Ying-Ai Wang2, Tian-Yang Gao2, Xiao-Jing Wang2, Yun-Xue Zhao3.
Abstract
The fruits of Paulownia catalpifolia Gong Tong are used as a Chinese folk herbal medicine for the treatment of enteritis, tonsillitis, bronchitis, and dysentery, etc. Our previous study has identified new C-geranylated flavanones with obvious anti-proliferative effects in lung cancer A549 cells. In the present study, a new C-geranylated flavone, paucatalinone C (1) and five known C-geranylated flavanones (2-6) were isolated. In addition, a total of 34 C-geranylated flavonoids were detected by HPLC-DAD-ESI-MS/MS coupling techniques from the CH2Cl2 extract of P. catalpifolia. Futhermore, anti-aging effects of isolated compounds were evaluated in vitro with premature senescent 2BS cells induced by H2O2. Phytochemical results indicated that P. catalpifolia was a natural resource of abundant C-geranylated flavonoids. Diplacone (3) and paucatalinone A (5) were the potent anti-aging agents in the premature senescent 2BS cells induced by H2O2 and the C-geranyl substituent may be an important factor because of its lipophilic character.Entities:
Keywords: 2BS cells; Anti-aging effects; C-geranylated flavonoids; HPLC-DAD-ESI-MS/MS; Paucatalinone C; Paulownia catalpifolia Gong Tong
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Year: 2017 PMID： 28558874 PMCID： PMC7130034 DOI： 10.1016/S1875-5364(17)30059-6
Source DB: PubMed Journal: Chin J Nat Med ISSN： 1875-5364