| Literature DB >> 28558629 |
Pankaj Wadhwa1, Priti Jain1, Santosh Rudrawar2,3, Hemant R A Jadhav1.
Abstract
Human Immunodeficiency Virus Type 1 Integrase or HIV-1 integrase (IN) is a 288 amino acid protein that incorporates the retrotranscribed viral DNA into the host chromosomal DNA. Over the past 30 years, large number of derivatives have been evaluated for their inhibitory potential against IN. There is vast literature available which need to be collated to help scientists plan the future drug design. This review discusses the reports of past 25 years on analogs of quinoline, coumarin and other related heterocycles, which exhibit low micromolar inhibitory potency against IN. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.Entities:
Keywords: 3'-end processing inhibitors; HIV-1 integrase; coumarins; heterocyclic analogs; quinolines; strand transfer inhibitors
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Year: 2018 PMID： 28558629 DOI： 10.2174/1570163814666170531115452
Source DB: PubMed Journal: Curr Drug Discov Technol ISSN： 1570-1638