Pierre Philouze1, Julien Péron2, Marc Poupart1, Kevin Pujo3, Guillaume Buiret3, Philippe Céruse1,4. 1. Department of Head and Neck Surgery, Hospital de la Croix Rousse Hospices Civils de Lyon, Lyon, France. 2. Biostatistics Department, CHU Lyon Sud, Hospices Civils de Lyon, Pierre, Benité, France. 3. Department of Ear, Nose, and Throat, Valence Hospital, Valence, France. 4. The University of Lyon 1, France.
Abstract
BACKGROUND: In the case of a locoregional recurrence of oropharyngeal squamous cell carcinoma, the curative standard of care is surgery. Our main purpose of this study was to determine the preoperative prognostic factors that would allow us to select the patients on whom we could expect good results with salvage surgery. METHODS: We conducted a monocentric retrospective study from 2005 to 2013. It included all patients treated for a recurrence of oropharyngeal squamous cell carcinoma with surgery. Their initial treatment included radiotherapy. RESULTS: Fifty-two patients were included. Poor prognostic factors for survival were the cT status (P = .0039) and local recurrences versus secondary localizations in irradiated areas (P = .016) and a relapse less than a year after the end of the initial treatment (P = .050). Recurrence-free survival was 19% at 5 years. Twenty-nine percent of patients presented local complications, which were mainly fistulas and hemorrhaging at the surgical site. CONCLUSION: According to the high morbimortality, it is important to carefully select the right patients for surgery.
BACKGROUND: In the case of a locoregional recurrence of oropharyngeal squamous cell carcinoma, the curative standard of care is surgery. Our main purpose of this study was to determine the preoperative prognostic factors that would allow us to select the patients on whom we could expect good results with salvage surgery. METHODS: We conducted a monocentric retrospective study from 2005 to 2013. It included all patients treated for a recurrence of oropharyngeal squamous cell carcinoma with surgery. Their initial treatment included radiotherapy. RESULTS: Fifty-two patients were included. Poor prognostic factors for survival were the cT status (P = .0039) and local recurrences versus secondary localizations in irradiated areas (P = .016) and a relapse less than a year after the end of the initial treatment (P = .050). Recurrence-free survival was 19% at 5 years. Twenty-nine percent of patients presented local complications, which were mainly fistulas and hemorrhaging at the surgical site. CONCLUSION: According to the high morbimortality, it is important to carefully select the right patients for surgery.
Authors: Molly E Heft Neal; Julia Brennan; Catherine T Haring; J Chad Brenner; Francis Worden; Paul Swiecicki; Michelle Mierzwa; Keith A Casper; Kelly M Malloy; Chaz L Stucken; Scott A McLean; Mark E Prince; Carol R Bradford; Gregory T Wolf; Andrew G Shuman; Steven B Chinn; Douglas B Chepeha; Andrew J Rosko; Matthew E Spector Journal: Eur Arch Otorhinolaryngol Date: 2020-03-19 Impact factor: 2.503
Authors: Marc Hamoir; Sandra Schmitz; Carlos Suarez; Primoz Strojan; Kate A Hutcheson; Juan P Rodrigo; William M Mendenhall; Ricard Simo; Nabil F Saba; Anil K D'Cruz; Missak Haigentz; Carol R Bradford; Eric M Genden; Alessandra Rinaldo; Alfio Ferlito Journal: Cancers (Basel) Date: 2018-08-10 Impact factor: 6.639