Literature DB >> 2855458

Comparative in vitro and in vivo activity of rifabutin and rifampicin against Mycobacterium avium complex.

H Saito1, K Sato, H Tomioka.   

Abstract

In vitro antimicrobial activity of rifabutin and rifampicin against various mycobacteria, including the Mycobacterium avium complex, was evaluated by the agar dilution method, using 7H10 agar medium. The activity of rifabutin based on MIC50 and MIC90 was higher than that of rifampicin, against all the acid-fast organisms tested. Microbicidal activity of rifabutin against the M. avium complex phagocytosed in mouse peritoneal or alveolar macrophages was greater than that of rifampicin. Both rifabutin and rifampicin had therapeutic effects against murine infections induced by M. avium complex. Rifabutin was somewhat more effective than rifampicin in mice.

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Year:  1988        PMID： 2855458     DOI： 10.1016/0041-3879(88)90020-7

Source DB:  PubMed          Journal:  Tubercle        ISSN： 0041-3879


  17 in total

1.  In vitro antimycobacterial activities of newly synthesized benzoxazinorifamycins.

Authors:  H Saito; H Tomioka; K Sato; M Emori; T Yamane; K Yamashita; K Hosoe; T Hidaka
Journal:  Antimicrob Agents Chemother       Date:  1991-03       Impact factor: 5.191

Review 2.  Bacterial challenges and evolving antibacterial drug strategy.

Authors:  B Watt; J G Collee
Journal:  Postgrad Med J       Date:  1992-01       Impact factor: 2.401

Review 3.  Antimycobacterial susceptibility testing: present practices and future trends.

Authors:  C B Inderlied
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1994-11       Impact factor: 3.267

4.  In vivo activities of newer rifamycin analogs against Mycobacterium avium infection.

Authors:  S P Klemens; M H Cynamon
Journal:  Antimicrob Agents Chemother       Date:  1991-10       Impact factor: 5.191

5.  Therapeutic efficacy of liposomal rifabutin in a Mycobacterium avium model of infection.

Authors:  M M Gaspar; S Neves; F Portaels; J Pedrosa; M T Silva; M E Cruz
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

6.  A bone marrow-derived murine macrophage model for evaluating efficacy of antimycobacterial drugs under relevant physiological conditions.

Authors:  P S Skinner; S K Furney; M R Jacobs; G Klopman; J J Ellner; I M Orme
Journal:  Antimicrob Agents Chemother       Date:  1994-11       Impact factor: 5.191

7.  Comparative in vivo activities of rifabutin and rifapentine against Mycobacterium avium complex.

Authors:  S P Klemens; M A Grossi; M H Cynamon
Journal:  Antimicrob Agents Chemother       Date:  1994-02       Impact factor: 5.191

Review 8.  The Mycobacterium avium complex.

Authors:  C B Inderlied; C A Kemper; L E Bermudez
Journal:  Clin Microbiol Rev       Date:  1993-07       Impact factor: 26.132

9.  Therapeutic efficacy of liposome-entrapped rifampin against Mycobacterium avium complex infection induced in mice.

Authors:  H Saito; H Tomioka
Journal:  Antimicrob Agents Chemother       Date:  1989-04       Impact factor: 5.191

Review 10.  Clinical pharmacokinetics of rifabutin.

Authors:  M H Skinner; T F Blaschke
Journal:  Clin Pharmacokinet       Date:  1995-02       Impact factor: 6.447
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