Nat Ketumarn1, Dittakarn Boriboonhirunsarn1. 1. a Department of Obstetrics and Gynaecology, Faculty of Medicine, Siriraj Hospital , Mahidol University , Bangkok , Thailand.
Abstract
OBJECTIVES: To describe the characteristics of abnormal oral glucose tolerance test (OGTT) values at gestational diabetes mellitus (GDM) diagnosis and their associations with clinical characteristics, and to evaluate the effect on GDM diagnosis if any OGTT value was omitted. MATERIALS AND METHODS: A cross-sectional study was conducted in 415 women diagnosed with GDM. The OGTT results were recorded and analyzed. RESULTS: Of the 415 included women, mean gestational age at GDM diagnosis was 19.2 weeks and 57.6% were diagnosed before 20 weeks. The highest proportions of abnormal values were found at the 1st and 2nd hour (85.3% and 96.6%, respectively). If the 3rd hour OGTT value was omitted, 16.7% of GDM cases would be missed. Number of abnormal OGTT values and abnormal FPG were significantly associated with obesity. Only pre-pregnancy overweight and obesity independently associated with insulin requirement (adjusted OR: 2.28, 95%CI: 1.02-5.06; p = .044; and adjusted OR: 6.29, 95%CI: 2.67-14.85; p < .001, respectively). CONCLUSIONS: Over half of the GDM women had three or four abnormal OGTT values. Omission of the 3rd hour OGTT value would result in 16.7% of patients not being diagnosed with GDM. Number of abnormal OGTT values and abnormal FPG were associated with obesity, and insulin requirement was associated with pre-pregnancy overweight and obesity.
OBJECTIVES: To describe the characteristics of abnormal oral glucose tolerance test (OGTT) values at gestational diabetes mellitus (GDM) diagnosis and their associations with clinical characteristics, and to evaluate the effect on GDM diagnosis if any OGTT value was omitted. MATERIALS AND METHODS: A cross-sectional study was conducted in 415 women diagnosed with GDM. The OGTT results were recorded and analyzed. RESULTS: Of the 415 included women, mean gestational age at GDM diagnosis was 19.2 weeks and 57.6% were diagnosed before 20 weeks. The highest proportions of abnormal values were found at the 1st and 2nd hour (85.3% and 96.6%, respectively). If the 3rd hour OGTT value was omitted, 16.7% of GDM cases would be missed. Number of abnormal OGTT values and abnormal FPG were significantly associated with obesity. Only pre-pregnancy overweight and obesity independently associated with insulin requirement (adjusted OR: 2.28, 95%CI: 1.02-5.06; p = .044; and adjusted OR: 6.29, 95%CI: 2.67-14.85; p < .001, respectively). CONCLUSIONS: Over half of the GDM women had three or four abnormal OGTT values. Omission of the 3rd hour OGTT value would result in 16.7% of patients not being diagnosed with GDM. Number of abnormal OGTT values and abnormal FPG were associated with obesity, and insulin requirement was associated with pre-pregnancy overweight and obesity.
Authors: Sharon P Luccisano; Heinrich C Weber; Giuliana O Murfet; Iain K Robertson; Sarah J Prior; Andrew P Hills Journal: Int J Environ Res Public Health Date: 2021-11-16 Impact factor: 3.390
Authors: Gilberte Martine-Edith; William Johnson; Eugenie Hunsicker; Mark Hamer; Emily S Petherick Journal: BMJ Open Date: 2021-11-03 Impact factor: 2.692
Authors: Aida Kalok; Ming Yean Ong; Aqilah Hasrori; Ker Shing Chiang; Fatin Yazim; Salahuddin Baharuddin; Rahana Abdul Rahman; Shamsul Azhar Shah; Nor Haslinda Abd Aziz; Shuhaila Ahmad; Nor Azlin Mohamed Ismail Journal: Int J Environ Res Public Health Date: 2020-09-24 Impact factor: 3.390