J A Peña-Zarza1, M De la Peña2, A Yañez3, J M Bauça3,4, D Morell-Garcia5,6, M Caimari7, A Barceló3,4, J Figuerola1. 1. Pulmonology and Sleep Disorders Section, Department of Pediatrics, Hospital Universitari Son Espases, Palma de Mallorca, Spain. 2. Respiratory Department, Hospital Universitari Son Espases, Palma de Mallorca, Spain. 3. Institut d'Investigació Sanitària de Palma (IdISPa), Palma de Mallorca, Spain. 4. Department of Laboratory Medicine, Hospital Universitari Son Espases, Ctra. de Valldemossa, 79, 07120, Palma de Mallorca, Balearic Islands, Spain. 5. Institut d'Investigació Sanitària de Palma (IdISPa), Palma de Mallorca, Spain. dr.morell.uab@gmail.com. 6. Department of Laboratory Medicine, Hospital Universitari Son Espases, Ctra. de Valldemossa, 79, 07120, Palma de Mallorca, Balearic Islands, Spain. dr.morell.uab@gmail.com. 7. Endocrinology Section, Department of Pediatrics, Hospital Universitari Son Espases, Palma de Mallorca, Spain.
Abstract
PURPOSE: Snoring and obstructive sleep apnea syndrome (OSA) are frequent conditions in pediatrics. Glycated hemoglobin (HbA1C) is a useful homeostatic biomarker of glycemia and may reflect alterations deriving from sleep breathing disorders. The aim of this study was to relate the severity of OSA with blood HbA1C levels in children. METHODS: A descriptive observational study in snoring patients was performed. All patients underwent a sleep study and classified either as simple snorers (apnea-hypopnea index; AHI ≤ 1 episodies/h) or as OSA patients (AHI > 1 episodes/h). In the following morning, a blood glycemic profile (fasting glucose, insulin, HbA1C, and the HOMA index) was performed to every individual. RESULTS: A total of 48 patients were included. HbA1C levels were shown to be increased in the moderate OSA (AHI > 5 episodes/h) group (5.05 ± 0.25 vs. 5.24 ± 0.29%; p = 0.019). Significant correlations were found between HbA1C values and AHI (r = 0.345; p = 0.016) and also with oxygen desaturation index (r = 0.40; p = 0.005). Correlations remained significant after adjusting by age and body mass index. The AHI-associated change in HbA1C was 13.4% (p = 0.011). CONCLUSIONS: In the pediatric population, HbA1C is a biomarker associated with OSA severity, and this relationship is age- and obesity-independent. The fact that this association was observed in snoring patients could help the physician in the distinction between those patients affected with OSA and those with simple snoring. Therefore, HbA1C measurement could play a major role in the diagnosis and the management of the syndrome.
PURPOSE: Snoring and obstructive sleep apnea syndrome (OSA) are frequent conditions in pediatrics. Glycated hemoglobin (HbA1C) is a useful homeostatic biomarker of glycemia and may reflect alterations deriving from sleep breathing disorders. The aim of this study was to relate the severity of OSA with blood HbA1C levels in children. METHODS: A descriptive observational study in snoring patients was performed. All patients underwent a sleep study and classified either as simple snorers (apnea-hypopnea index; AHI ≤ 1 episodies/h) or as OSA patients (AHI > 1 episodes/h). In the following morning, a blood glycemic profile (fasting glucose, insulin, HbA1C, and the HOMA index) was performed to every individual. RESULTS: A total of 48 patients were included. HbA1C levels were shown to be increased in the moderate OSA (AHI > 5 episodes/h) group (5.05 ± 0.25 vs. 5.24 ± 0.29%; p = 0.019). Significant correlations were found between HbA1C values and AHI (r = 0.345; p = 0.016) and also with oxygen desaturation index (r = 0.40; p = 0.005). Correlations remained significant after adjusting by age and body mass index. The AHI-associated change in HbA1C was 13.4% (p = 0.011). CONCLUSIONS: In the pediatric population, HbA1C is a biomarker associated with OSA severity, and this relationship is age- and obesity-independent. The fact that this association was observed in snoring patients could help the physician in the distinction between those patients affected with OSA and those with simple snoring. Therefore, HbA1C measurement could play a major role in the diagnosis and the management of the syndrome.
Authors: Ronald D Chervin; Susan S Ellenberg; Xiaoling Hou; Carole L Marcus; Susan L Garetz; Eliot S Katz; Elise K Hodges; Ron B Mitchell; Dwight T Jones; Raanan Arens; Raouf Amin; Susan Redline; Carol L Rosen Journal: Chest Date: 2015-11 Impact factor: 9.410
Authors: D López de Lara; P Santiago Paniagua; M Tapia Ruiz; M D Rodríguez Mesa; R Gracia Bouthelier; A Carrascosa Lezcano Journal: An Pediatr (Barc) Date: 2010-08-05 Impact factor: 1.500
Authors: Carole L Marcus; Lee Jay Brooks; Kari A Draper; David Gozal; Ann Carol Halbower; Jacqueline Jones; Michael S Schechter; Sally Davidson Ward; Stephen Howard Sheldon; Richard N Shiffman; Christopher Lehmann; Karen Spruyt Journal: Pediatrics Date: 2012-08-27 Impact factor: 7.124