Hippocampal Sclerosis in a Child with Multiple Neurocysticercosis.

Dear Sir,

A 7-year-old female child presented with the complaints of three episodes of the left focal seizures over a span of 16 months. Contrast-enhanced magnetic resonance imaging (MRI) brain with coronal (Panels A and D) and sagittal (Panels B and C) cuts depicted multiple peripheral ring-enhancing lesions seen in bilateral cerebral hemispheres, basal ganglia, thalami, midbrain, and cerebellar hemispheres suggestive of neurocysticercosis (NCC). She was given cysticidal therapy (albendazole for 28 days) under steroid cover and was started on eptoin (6.5 mg/kg/day). She remained seizure free for the next 2 years when a repeat plain MRI brain with axial (Panel E), sagittal (Panels F), and coronal (Panel G) cuts depicted single disc-shaped lesion measuring 7.5 mm in the left temporoparietal region with calcification. Anterior head part of the right hippocampus appeared smaller as compared to the left side suggestive of hippocampal sclerosis (HS). This child has continued to remain seizure free during a follow-up period of 1.5 years despite evident right HS.

Recent observations suggest that NCC might act as an initial precipitating injury causing mesial temporal lobe epilepsy associated with HS through two main pathophysiological mechanisms: inflammation-mediated and electrogenic-mediated.[12] This case wherein follow-up neuroimaging studies have revealed the development of HS 2 years after the diagnosis of NCC lends support to the hypothesis that NCC can be a causative factor in the development of HS and potential mechanism seems to be inflammation-mediated and not recurrent seizures. Another unusual finding, in this case, has been nondevelopment of refractory epilepsy despite the presence of HS. This observation needs confirmation through future studies as it suggests that damage to hippocampus in NCC patients might not render it epileptogenic leading to refractory epilepsy.

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