Physicochemical and colloidal aspects of food matrix effects on gastrointestinal fate of ingested inorganic nanoparticles.

Inorganic nanoparticles, such as titanium dioxide, silicon dioxide, iron oxide, zinc oxide, or silver nanoparticles, are added to some food products and food packaging materials to obtain specific functional attributes, such as lightening, powder flow, nutrition, or antimicrobial properties. These engineered nanomaterials (ENMs) all have dimensions below 100nm, but may still vary considerably in composition, morphology, charge, surface properties and aggregation state, which effects their gastrointestinal fate and potential toxicity. In addition to their intrinsic physicochemical and morphological properties, the extrinsic properties of the media they are suspended in also affects their biotransformation, gastrointestinal fate and bioactivity. For instance, inorganic nanoparticles are usually consumed as part of a food or meal that contains numerous other components, such as lipids, proteins, carbohydrates, surfactants, minerals, and water, which may alter their gastrointestinal fate. This review article provides an overview of the potential effects of food components on the behavior of ENMs in the gastrointestinal tract (GIT), and highlights some important physicochemical and colloidal mechanisms by which the food matrix may alter the properties of inorganic nanoparticles. This information is essential for developing appropriate test methods to establish the potential toxicity and biokinetics of inorganic nanoparticles in foods.