Literature DB >> 2855214

N-methyl-D-aspartate receptors mediate tonic vasodepressor control in the caudal ventrolateral medulla of the rat.

T Kubo1, M Kihara.   

Abstract

Microinjections of N-methyl-D-aspartate (NMDA) into the caudal ventrolateral medulla of the rat led to a decrease in arterial pressure whereas 2-amino-5-phosphonovalerate injected bilaterally into this region produced hypertension and blocked the depressor effect of aortic nerve stimulation. High K+ stimulation via push-pull cannula caused a calcium-dependent release of endogenous glutamate from the region. These results provide evidence for the NMDA receptor system involved in tonic vasodepressor control in the rat caudal ventrolateral medulla.

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Year:  1988        PMID： 2855214     DOI： 10.1016/0006-8993(88)90786-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

1.  On the role of NMDA receptors in blood pressure regulation in spontaneously hypertensive rats (SHR).

Authors:  S Glazewski; M Remiszewska; M Wutkiewicz; Z Jastrzebski; W Danysz
Journal:  Amino Acids       Date:  1995-12       Impact factor: 3.520

2.  Baroreceptor-vasomotor reflex after N-methyl-D-aspartate receptor blockade in rabbit caudal ventrolateral medulla.

Authors:  W W Blessing
Journal:  J Physiol       Date:  1989-09       Impact factor: 5.182

3.  Ipsilateral but not contralateral blockade of excitatory amino acid receptors in the caudal ventrolateral medulla inhibits aortic baroreceptor reflex in rats.

Authors:  T Kubo; M Kihara; Y Misu
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-01       Impact factor: 3.000

4.  Unilateral blockade of excitatory amino acid receptors in the nucleus tractus solitarii produces an inhibition of baroreflexes in rats.

Authors:  T Kubo; M Kihara
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-03       Impact factor: 3.000

5.  Excitatory amino acid receptors in the caudal ventrolateral medulla mediate a vagal cardiopulmonary reflex in the rat.

Authors:  A J Verberne; P M Beart; W J Louis
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

6.  Involvement of both GABAA and GABAB receptors in tonic inhibitory control of blood pressure at the rostral ventrolateral medulla of the rat.

Authors:  M Amano; T Kubo
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-08       Impact factor: 3.000

7.  Blockade of excitatory amino acid receptors in the ventrolateral medulla does not abolish the cardiovascular actions of L-glutamate.

Authors:  Z J Gieroba; W W Blessing
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-01       Impact factor: 3.000

8.  Frequency-dependent facilitation of synaptic throughput via postsynaptic NMDA receptors in the nucleus of the solitary tract.

Authors:  Huan Zhao; James H Peters; Mingyan Zhu; Stephen J Page; Robert C Ritter; Suzanne M Appleyard
Journal:  J Physiol       Date:  2014-11-03       Impact factor: 5.182
  8 in total

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