Gen Suzuki1, Hideya Yamazaki2, Norihiro Aibe2, Koji Masui2, Kotoha Tatekawa2, Naomi Sasaki2, Takuya Kimoto2, Takeshi Nishimura2, Akihiro Nakashima2, Tadashi Takenaka2, Hitoshi Fujiwara3, Takeshi Ishikawa4, Kei Yamada2. 1. Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan gensuzu@koto.kpu-m.ac.jp. 2. Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. 3. Department of Digestive Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. 4. Department of Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Abstract
AIM: To clarify the role of external-beam radiotherapy in the local management of state IVB esophageal cancer. PATIENTS AND METHODS: We reviewed records of 31 patients with histopathologically-proven squamous cell carcinoma who underwent radiotherapy for their primary lesion. The change in dysphagia score from before to after treatment was assessed. Nutritional support-free survival (NSFS) was also evaluated. RESULTS: The median overall survival was 6 months. The overall rate of improvement in dysphagia score was 73% (23/31). The median NSFS was 5 months. Age at presentation <67 years, tumor location in the middle thoracic esophagus, and tumor length <7 cm were associated with significant improvement in swallowing scores. Responders to radiotherapy had significantly longer NSFS than non-responders (p=0.04). CONCLUSION: Palliative radiotherapy in the local management of stage IVB esophageal cancer is an effective treatment option for dysphagia. Factors highly associated with improvement of swallowing are age, tumor location, and tumor length. Response to radiotherapy is the most important factor in improving NSFS. Copyright
AIM: To clarify the role of external-beam radiotherapy in the local management of state IVB esophageal cancer. PATIENTS AND METHODS: We reviewed records of 31 patients with histopathologically-proven squamous cell carcinoma who underwent radiotherapy for their primary lesion. The change in dysphagia score from before to after treatment was assessed. Nutritional support-free survival (NSFS) was also evaluated. RESULTS: The median overall survival was 6 months. The overall rate of improvement in dysphagia score was 73% (23/31). The median NSFS was 5 months. Age at presentation <67 years, tumor location in the middle thoracic esophagus, and tumor length <7 cm were associated with significant improvement in swallowing scores. Responders to radiotherapy had significantly longer NSFS than non-responders (p=0.04). CONCLUSION: Palliative radiotherapy in the local management of stage IVB esophageal cancer is an effective treatment option for dysphagia. Factors highly associated with improvement of swallowing are age, tumor location, and tumor length. Response to radiotherapy is the most important factor in improving NSFS. Copyright
Authors: Lei Wu; Juan Liu; Long Liang; Mian Mao; Xiangpan Li; Tao Li; Jinyi Lang; Qifeng Wang Journal: Front Oncol Date: 2022-05-25 Impact factor: 5.738