Susan L Neuhausen1, Hagit Shani2, Lital Keinan Boker3, Linda Steele1, Barbara G Silverman3, Laura Ottini4, Valentina Silvestri4, Yael Laitman2, Jacob Korach5,6, Tamar Perri6, Eitan Friedman7,5,8. 1. Department of Population Sciences, Research Institute, City of Hope, Duarte, CA, U.S.A. 2. Oncogenetics Unit, Chaim Sheba Medical Center, Tel-Hashomer, Israel. 3. Israeli National Cancer Registry, Tel-Hashomer, Israel. 4. Department of Molecular Medicine, La Sapienza University of Rome, Rome, Italy. 5. Meirav High-risk Clinic, Chaim Sheba Medical Center, Tel-Hashomer, Israel. 6. Gyneco-oncology Department, Chaim Sheba Medical Center, Tel-Hashomer, Israel. 7. Oncogenetics Unit, Chaim Sheba Medical Center, Tel-Hashomer, Israel feitan@post.tau.ac.il eitan.friedman@sheba.health.gov.il. 8. Department of Genetics and Biochemistry, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Abstract
BACKGROUND: Primary peritoneal serous carcinoma (PPSC) is a rare neoplasm. The paucity of reported cases among men may provide insight to the cell of origin of PPSC. MATERIALS AND METHODS: A search for the ICD 0-3 code of PPSC (C48.2) in the following datasets: the Israeli National Cancer registry (INCR), the Surveillance, Epidemiology, and End Results (SEER) database in the USA, Israeli male BRCA carriers, male high-risk and BRCA carriers in a USA study, and the Italian Study on Male Breast Cancer (MBC) were performed. RESULTS: In the INCR dataset, 220 entries for C48.2 code were noted, with only one male (male:female ratio=0.0045). In the SEER dataset for histology codes of papillary/serous/ adenocarcinoma, 2,673 cases were recorded, with five males (male:female ratio=0.0018). None of the recorded US or Italian male BRCA carriers or MBC, or Israeli male BRCA carriers was diagnosed with PPSC. CONCLUSION: PPSC is a rare neoplasm, seemingly not associated with BRCA mutations in men, and fallopian tube epithelial cell implants may contribute to its development. Copyright
BACKGROUND:Primary peritoneal serous carcinoma (PPSC) is a rare neoplasm. The paucity of reported cases among men may provide insight to the cell of origin of PPSC. MATERIALS AND METHODS: A search for the ICD 0-3 code of PPSC (C48.2) in the following datasets: the Israeli National Cancer registry (INCR), the Surveillance, Epidemiology, and End Results (SEER) database in the USA, Israeli male BRCA carriers, male high-risk and BRCA carriers in a USA study, and the Italian Study on Male Breast Cancer (MBC) were performed. RESULTS: In the INCR dataset, 220 entries for C48.2 code were noted, with only one male (male:female ratio=0.0045). In the SEER dataset for histology codes of papillary/serous/ adenocarcinoma, 2,673 cases were recorded, with five males (male:female ratio=0.0018). None of the recorded US or Italian male BRCA carriers or MBC, or Israeli male BRCA carriers was diagnosed with PPSC. CONCLUSION: PPSC is a rare neoplasm, seemingly not associated with BRCA mutations in men, and fallopian tube epithelial cell implants may contribute to its development. Copyright