Cell biology-metabolic crosstalk in glioma.

The renewed interest in cancer metabolism in recent years has been fuelled by the identification of the involvement of key oncogenes and tumour suppressor genes in the control of metabolic pathways. Many of these alterations lead to dramatic changes in bioenergetics, biosynthesis and redox balance within tumour cells. The complex relationship between tumour cell metabolism and the tumour microenvironment has turned this field of biochemistry and cell biology into a challenging and exciting area for study. In the case of gliomas the involvement of altered metabolic pathways including glycolysis, oxidative phosphorylation and glutaminolysis are pointing the way to new possibilities for treatment. The tumour-promoting effects of inflammation are an emerging hallmark of cancer and the role of the eicosanoids in gliomas is an area of active research to elucidate the importance of individual eicosanoids in glioma cell proliferation, migration and immune escape. In this review, the different aspects of metabolic reprogramming which occur in gliomas are highlighted and their relationship to glioma cell biology and the wider tumour microenvironment is described.