William L Miller1, W David Walter2. 1. Pennsylvania Cooperative Fish and Wildlife Research Unit, Department of Ecosystem Science and Management, Intercollege Graduate Degree Program in Ecology, The Pennsylvania State University, University Park, PA 16802, USA. 2. U.S. Geological Survey, Pennsylvania Cooperative Fish and Wildlife Research Unit, The Pennsylvania State University, University Park, PA 16802, USA.
Abstract
SUMMARY: Chronic wasting disease is a fatal, neurological disease caused by an infectious prion protein, which affects economically and ecologically important members of the family Cervidae. Single nucleotide polymorphisms within the prion protein gene have been linked to differential susceptibility to the disease in many species. Wildlife managers are seeking to determine the frequencies of disease-associated alleles and genotypes and delineate spatial genetic patterns. The CWDPRNP package, implemented in program R, provides a unified framework for analyzing prion protein gene variability and spatial structure. AVAILABILITY AND IMPLEMENTATION: The CWDPRNP package, manual and example data files are available at http://ecosystems.psu.edu/research/labs/walter-lab/additional-labs/population-genetics-lab. This package is available for all commonly used platforms. CONTACT: wlm159psu@gmail.com. Published by Oxford University Press 2017. This work is written by US Government employees and are in the public domain in the US.
SUMMARY: Chronic wasting disease is a fatal, neurological disease caused by an infectious prion protein, which affects economically and ecologically important members of the family Cervidae. Single nucleotide polymorphisms within the prion protein gene have been linked to differential susceptibility to the disease in many species. Wildlife managers are seeking to determine the frequencies of disease-associated alleles and genotypes and delineate spatial genetic patterns. The CWDPRNP package, implemented in program R, provides a unified framework for analyzing prion protein gene variability and spatial structure. AVAILABILITY AND IMPLEMENTATION: The CWDPRNP package, manual and example data files are available at http://ecosystems.psu.edu/research/labs/walter-lab/additional-labs/population-genetics-lab. This package is available for all commonly used platforms. CONTACT: wlm159psu@gmail.com. Published by Oxford University Press 2017. This work is written by US Government employees and are in the public domain in the US.
Authors: Alberto F Fameli; Jessie Edson; Jeremiah E Banfield; Christopher S Rosenberry; W David Walter Journal: Prion Date: 2022-12 Impact factor: 2.547