Markus K H Wiedmann1,2,3, Cathrine Brunborg4, Antonio Di Ieva2, Kristina Lindemann3,5, Tom B Johannesen6, Lars Vatten7, Eirik Helseth1,3, John A Zwart3,8. 1. a Department of Neurosurgery , Oslo University Hospital , Ulleval , Oslo , Norway. 2. b Neurosurgery Unit, Faculty of Medicine and Health Sciences , Macquarie University , Sydney , NSW , 2109 , Australia. 3. c Institute of Clinical Medicine, Faculty of Medicine , University of Oslo , Oslo , Norway. 4. d Oslo Centre for Biostatistics and Epidemiology, Research Support Services , Oslo University Hospital , Oslo , Norway. 5. e Department of Gynecologic Oncology , Norwegian Radium Hospital, Oslo University Hospital , Oslo , Norway. 6. f The Cancer Registry of Norway , Oslo , Norway. 7. g Department of Public Health , Norwegian University of Science and Technology , Trondheim , Norway. 8. h FORMI and Department of Neurology , Oslo University Hospital, Ulleval , Oslo , Norway.
Abstract
BACKGROUND: In 2016, the International Agency for Research on Cancer (IARC) has announced that avoiding body fatness (i.e. overweight and obesity) contributes to prevent meningioma occurrence, but considered the available evidence for glioma inadequate. The association of body fatness with other CNS tumor subgroups is largely unknown. OBJECTIVES: To assess whether body fatness or body height are associated with risk for meningioma, glioma, pituitary adenoma (PA) or nerve sheath tumor (NST) in a large population-based Norwegian cohort. METHODS: In this prospective cohort study of 1.8 million Norwegian residents, weight and height were measured at baseline and incident intracranial tumors were subsequently identified by linkage to the Cancer Registry of Norway. Cox regression analyses were performed to estimate risk for each tumor subgroup in relation to anthropometric measures, stratified by sex and in different age groups. RESULTS: During 54 million person-years of follow-up 3335 meningiomas, 4382 gliomas, 1071 PAs and 759 NSTs were diagnosed. Obesity (BMI ≥30 kg/m2) was not associated with risk for meningioma or glioma, but was significantly associated with risk for PA (HR 1.43; 95% CI 1.09-1.88) compared with the reference group (BMI 20-24.9 kg/m2). For intracranial NSTs, obesity was associated with reduced tumor risk (HR 0.68; 95% CI 0.46-0.99). Body height was associated with increased risk for all four tumor subgroups. CONCLUSIONS: This study does not confirm overweight or obesity as risk factors for meningioma. Additionally, overweight and obesity can be quite confidently excluded as risk factors for glioma. However, this study indicates that body fatness increases the risk for PA, while it reduces the risk for NST.
BACKGROUND: In 2016, the International Agency for Research on Cancer (IARC) has announced that avoiding body fatness (i.e. overweight and obesity) contributes to prevent meningioma occurrence, but considered the available evidence for glioma inadequate. The association of body fatness with other CNS tumor subgroups is largely unknown. OBJECTIVES: To assess whether body fatness or body height are associated with risk for meningioma, glioma, pituitary adenoma (PA) or nerve sheath tumor (NST) in a large population-based Norwegian cohort. METHODS: In this prospective cohort study of 1.8 million Norwegian residents, weight and height were measured at baseline and incident intracranial tumors were subsequently identified by linkage to the Cancer Registry of Norway. Cox regression analyses were performed to estimate risk for each tumor subgroup in relation to anthropometric measures, stratified by sex and in different age groups. RESULTS: During 54 million person-years of follow-up 3335 meningiomas, 4382 gliomas, 1071 PAs and 759 NSTs were diagnosed. Obesity (BMI ≥30 kg/m2) was not associated with risk for meningioma or glioma, but was significantly associated with risk for PA (HR 1.43; 95% CI 1.09-1.88) compared with the reference group (BMI 20-24.9 kg/m2). For intracranial NSTs, obesity was associated with reduced tumor risk (HR 0.68; 95% CI 0.46-0.99). Body height was associated with increased risk for all four tumor subgroups. CONCLUSIONS: This study does not confirm overweight or obesity as risk factors for meningioma. Additionally, overweight and obesity can be quite confidently excluded as risk factors for glioma. However, this study indicates that body fatness increases the risk for PA, while it reduces the risk for NST.
Authors: Jane H Cerhan; Alissa M Butts; Jeremy A Syrjanen; Jeremiah A Aakre; Paul D Brown; Ronald C Petersen; Clifford R Jack; Rosebud O Roberts Journal: Mayo Clin Proc Date: 2019-02 Impact factor: 7.616
Authors: J Almeida; J Costa; P Coelho; V Cea; M Galesio; J P Noronha; M S Diniz; C Prudêncio; R Soares; C Sala; Rúben Fernandes Journal: Metab Brain Dis Date: 2018-10-09 Impact factor: 3.584
Authors: Hannah Takahashi; Alex J Cornish; Amit Sud; Philip J Law; Linden Disney-Hogg; Lisa Calvocoressi; Lingeng Lu; Helen M Hansen; Ivan Smirnov; Kyle M Walsh; Johannes Schramm; Per Hoffmann; Markus M Nöthen; Karl-Heinz Jöckel; Joellen M Schildkraut; Matthias Simon; Melissa Bondy; Margaret Wrensch; Joseph L Wiemels; Elizabeth B Claus; Clare Turnbull; Richard S Houlston Journal: Sci Rep Date: 2019-01-22 Impact factor: 4.379