Manganese(I)-Catalyzed C-H 3,3-Difluoroallylation of Pyridones and Indoles.

A novel and efficient C-H activation approach for the direct 3,3-difluoroallylation of 2-pyridones and indoles is herein reported using a manganese(I) complex as the catalyst. A broad range of substrates with diverse functional groups were tolerated. Moreover, late-stage C-H functionalization of bioactive molecules was achieved in good yield.