Sumru Onal1,2, Merih Oray3, Cagla Yasa4, Mehmet Akman5, Gunay Uludag6, Aylin Koc Akbay6, Ilknur Tugal-Tutkun3. 1. a School of Medicine, Department of Ophthalmology , Koc University , Istanbul , Turkey. 2. b Department of Ophthalmology , V.K. Foundation, American Hospital , Istanbul , Turkey. 3. c Istanbul Faculty of Medicine, Department of Ophthalmology , Istanbul University , Istanbul , Turkey. 4. d School of Medicine, Koc University , Istanbul , Turkey. 5. e School of Medicine, Department of Family Medicine , Marmara University , Istanbul , Turkey. 6. f Department of Ophthalmology , Koc University Hospital , Istanbul , Turkey.
Abstract
PURPOSE: To screen for psychological disorders in patients with active uveitis. METHODS: Patients were screened for depression (BDI-II), state anxiety (STAI-I), VR-QOL (NEI-VFQ-25), and HR-QOL (SF-36). Association of depression and anxiety with sociodemographic and clinical parameters and with VR-QOL and HR-QOL were analyzed. Multivariate linear regression models were constructed for NEI-VFQ-25 and SF-36 subscales. RESULTS: Of 99 patients, 37.3% screened positive for depression and 52.5% for anxiety. Depressed patients had lower visual acuity in the better seeing eye (p = 0.013) and more frequently panuveitis (p = 0.018). Anxious patients were younger (p = 0.009), had earlier onset of uveitis (p = 0.015), and had more frequently panuveitis (p = 0.016). Bivariate comparisons showed significant associations between psychological disorders and VR-QOL and HR-QOL. Significant bivariate associations were mostly lost in multivariate analyses for anxiety, but were preserved for depression. CONCLUSIONS: A positive screening test for depression and anxiety is common in patients with uveitis. Low vision and panuveitis are associated with depression. Depression is associated with impairment of VR-QOL and HR-QOL.
PURPOSE: To screen for psychological disorders in patients with active uveitis. METHODS:Patients were screened for depression (BDI-II), state anxiety (STAI-I), VR-QOL (NEI-VFQ-25), and HR-QOL (SF-36). Association of depression and anxiety with sociodemographic and clinical parameters and with VR-QOL and HR-QOL were analyzed. Multivariate linear regression models were constructed for NEI-VFQ-25 and SF-36 subscales. RESULTS: Of 99 patients, 37.3% screened positive for depression and 52.5% for anxiety. Depressedpatients had lower visual acuity in the better seeing eye (p = 0.013) and more frequently panuveitis (p = 0.018). Anxious patients were younger (p = 0.009), had earlier onset of uveitis (p = 0.015), and had more frequently panuveitis (p = 0.016). Bivariate comparisons showed significant associations between psychological disorders and VR-QOL and HR-QOL. Significant bivariate associations were mostly lost in multivariate analyses for anxiety, but were preserved for depression. CONCLUSIONS: A positive screening test for depression and anxiety is common in patients with uveitis. Low vision and panuveitis are associated with depression. Depression is associated with impairment of VR-QOL and HR-QOL.
Entities:
Keywords:
Anxiety; BDI-II; NEI-VFQ-25; SF-36; STAI-I; depression; general health; quality of life; uveitis; vision
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